Biochemical Roles of Eukaryotic Cell Surface Macromolecules

Consists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.

Comprehensive critical reviews and original research papers from the 10th International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules Provides an in-depth analysis of cell surface macromolecules in cellular function Aimed at graduate students and researchers, but also appropriate for upper level undergraduates Includes supplementary material: sn.pub/extras

Inhalt

Human-Specific Evolutionary Changes in the Biology of Siglecs.- Structural Changes of GPI Anchor After Its Attachment to Proteins : Functional Significance.- Novel Insights In Membrane Biology Utilizing Fluorescence Recovery After Photobleaching.- Defects in Erythrocyte Membrane Skeletal Architecture.- Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55.- Immuno-Modulatory Role of Porins: Host Immune Responses, Signalling Mechanisms and Vaccine Potential.- Vibrio cholerae Cytolysin: Structure-Function Mechanism of an Atypical -barrel Pore-Forming Toxin.- New vis-tas in Lactosylceramide Research.- Plasma Membrane-Associated Sialidase Confers Cancer Initiation, Promotion and Progression.- A Signal with a Difference: The Role of GPI Anchor Signal Sequence in Dictating Conformation and Function of the Als5 Adhesin in Candida albicans .- Novel Chondroitin Sulfate Oligosaccharide Motifs as Biomarkers: Insights Into Their Involvement in Brain Development.- Role of Hyaluronidases in the Catabolism of Chondroitin Sulfate.- Pattern Recognition in Legume Lectins to Extrapolate Amino Acid Variability to Sugar Specificity.- Conformational Dynamics of Oligosaccharides Characterized by Paramagnetism-Assisted NMR Spectroscopy in Conjunction with Molecular Dynamics Simulation.- Characterization of Cholesterol Crystalline Domains in Model and Biological Membranes Using X-Ray Diffraction.- Role of Lipid-Mediated Effects in 2-Adrenergic Receptor Dimerization.- Effect of Temperature on the Phase Behaviour of Fully Saturated DAPC Lipid Bilayer: A Comparative Molecular Dynamics Simulation Study.- Biophysical Characterization of the Interaction of O-acylcholines with the Major Bovine Seminal Plasma Protein, PDC-109.- Crystal Structure of Apo and Ligand Bound Vibrio cholerae Ribokinase (Vc-RK): Role of Monovalent Cation Induced Activation and Structural Flexibility in Sugar Phosphorylation.- Synthetic Glycolipids and (p)ppGpp Analogs:Development of Inhibitors for Mycobacterial Growth, Biofilm and Stringent Response.- Regulations of Glycolipid : Glycosyltransferase (GSL: GLTs) Genes Involved in SA-LeX and Related GSLs Biosysthesis in Carcinoma Cells by Biosimilar Apoptotic Agents : Potential Anticancer Drugs.- N-acetylglucosaminyl 1-phosphate Transferase: An Excellent Target for Developing New Generation Breast Cancer Therapeutic.- Involvement of Vascular Endothelial Growth Factor in Serotonin 1A Receptor-Mediated Neuroproliferation in Neonatal Mouse Hippcampus.- Structural Heterogeneity of Glycoform of Alpha-1 Acid Glycoprotein in Alcoholic Cirrhosis Patients.