Since the first edition of this book there has been great progress in the development of genetically engineered mouse (GEM) models of cancer. This revised and updated edition comprehensively describes the state-of-the-art in animal tumor model research.

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Comprehensively describes in a new, updated edition the state-of-the-art in animal tumor model research. Includes syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Autorentext
Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.

Klappentext
Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research 2nd edition, provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Inhalt
TUMOR MODELS IN CANCER RESEARCH 2nd edition Beverly A Teicher Table of Contents INTRODUCTION 1. Perspectives on the History and Evolution of Tumor Models Shannon Decker and Edward Sausville TRANSPLANTABLE SYNGENEIC RODENT TUMORS 2. Murine L1210 and P388 Leukemias William R Waud 3. Transplantable Syngeneic Rodent Tumors Lisa Polin, Thomas H. Corbett, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White, Juiwanna Kushner, Stuart Hazeldine, Richard Moore, James Rake, and Jerome P. Horwitz 4. B16 Murine Melanomas : Historical Perspective on the Development of a Solid Tumor Model Enrique Alvarez HUMAN TUMOR XENOGRAFTS 5. Human Tumor Xenograft Efficacy Models Ming Liu and Daniel Hicklin 6. Imaging the Steps of Metastasis at the Macro and Cellular Level with Fluorescent Proteins in Real Time Robert M. Hoffman 7. Patient-derived Tumor Models and Explants Heinz-Herbert Fiebig and Angelika M. Burger 8. The Pediatric Preclinical Testing Program Christopher L. Morton and Peter J. Houghton 9. Imaging Efficacy in Tumor Models Vinod Kaimal, Wilbur R. Leopold, and Patrick McConville CARCINOGEN-INDUCED TUMORS 10. Mammary Cancer in Rats Henry J. Thompson DISEASE AND TARGET-SPECIFIC MODELS 11. Animal Models of Melanoma Ene T. Fairchild and William E. Carson, III 12. Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic Approaches Gilda G. Hillman 13. Animal Models of Mesothelioma Harvey I. Pass, Joseph B. Pincus Michele Carbone, and Magdalena Plasilova 14. The Use of Mouse Models to Study Leukemi /Lymphoma and Assess Therapeutic Approaches William Siders 15. Spontaneous Companion Animal (Pet) Cancers David M. Vail and Douglas H. Thamm GENETICALLY ENGINEERED MOUSE MODELS OF CANCER 16. Genetically Engineered Mouse Models of Pancreatic Ductal Adenocarcinoma Aram F. Hezel and Nabeel Bardeesy 17. Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP): A Validated Model for the Identification and Characterization of Molecular Targets and the Evaluation of Therapeutic Agents Sharon D. Morgenbesser 18. Transgenic Mouse Models for Cancer Prevention Research Stephen D. Hursting, Laura Lashinger, Powel Brown, Susan N. Perkins METASTASIS MODELS 19. Models for Evaluation of Targeted Therapies of Invasive and Metastatic Disease Suzanne A. Eccles NORMAL TISSUE RESPONSE MODELS 20. Animal Models of Toxicities caused by Anti-Neoplastic Therapy Stephen T. Sonis, Gregory Lyng, and Kimberly Pouliot 21. Bone Marrow as a Critical Normal Tissue Ralph Parchment 22. Anesthetic Considerations for the Study of Murine Tumor Models Thies Schroeder, Siqing Shan, Mark W. Dewhirst EXPERIMENTAL METHODS AND ENDPOINTS 23. Preclinical Tumor Response End Points Beverly A. Teicher 24. Tumor Cell Survival Sra Rockwell 25. Apoptosis In Vivo L.C. Stephens, Luka Milas, K.K. Ang, Katherine A. Mason, and Raymond E. Meyn 26. Transparent Window Models and Intravital Miceoscopy: Imaging Gene Expression, Physiological Function and Therapeutic Effects in Tumors Rakesh K. Jain, Lance L. Munn, and Dai Fukumura