This book aims to disseminate and review the latest interdisciplinary medical knowledge to provide information on best clinical practice for difficult-to-treat conditions.

The chapters address various aspects and approaches to the management of medical conditions that are not fully understood. This is exemplified by complex immune and inflammatory interactions in cancer development and survival-prolonging repeat surgery for pulmonary metastases or advances in craniotomy techniques for intracranial hemorrhage. Other chapters address the quality of life of patients after pyeloplasty, parathyroidectomy, or physically debilitating ankylosing spondylitis. Additional chapters address primary ciliopathies, a group of unclear genetic disorders affecting airway function, and dysfunctional airway remodeling underlying proinflammatory molecular mechanisms. The last few chapters address advances in the use of artificial intelligence for health management and in-silico experiments, whichis gaining importance in a variety of difficult-to-control conditions, such as endoprosthetic fixation in orthopedics. The book is dedicated to expanding knowledge in medical care by facilitating communication and discussion across medical disciplines. It is intended for clinical specialists, general practitioners, researchers, and members of all healthcare professions.

Introduces insightful clinical research Presents new knowledge and solutions Addresses diagnostic and therapeutic challenges

Inhalt

Artificial Intelligence in the Health Care System: An Overview.- Complex interaction among immune, inflammatory, and carcinogenic mechanisms in the head and neck squamous cell carcinoma.- Outcomes of Repeat Pulmonary Metastasectomy: An Evidence Review.- Quality of Life of Patients after Laparoscopic Pyeloplasty Due to Ureteropelvic Junction Obstruction: A Long-Term Observation.- Causes and Effects of Introducing Surgery Safety Checklist: A review.- Benefit of Biological Drugs for Quality of Life in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-Analysis of Clinical Trials.- Changes of Motile Ciliary Phenotype in Patients with Primary Ciliopathies.- Effects of Inhalation of STIM-Orai Antagonist SKF 96365 on Ovalbumin-Induced Airway Remodeling in Guinea Pigs.- In Silico Analysis of Bone Tension during Fixation of the Medial Malleolus Fracture after Ankle Joint Endoprosthesis .- Effects of Physical Activity at High Altitude on Hormonal Profiles in Foreign Trekkers and Indigenous Nepalese Porters.- Influence of Parathyroidectomy on Sleep Quality in Primary Hyperparathyroidism.- Mini Craniotomy in the Management of Supra-Tentorial Spontaneous Intracranial Hemorrhage; a Single-Center Outcome of the Minimally Invasive Treatment.