Molecular Cardiology for the Cardiologist, Second Edition provides a short, easily readable summary of what the new biology brings to cardiology. Special efforts have been made to include comprehensive diagrams and drawings, as well as teaching tables, and also to keep the size of the second edition within the modest limits of the first edition.
The book remains divided into 5 parts. The first part is a general introduction to the new terminology. The second part is devoted to the normal structure of the heart and vessels. Parts 3 and 4 deal with physiopathology. One of the important contributions of molecular biology to cardiology is a better understanding of the general process of adaptation of the heart and vessels to a permanent mechanical overloading. Such a process is generally called remodeling, and results from coordinate changes in the expression of the genes. The last part of the book includes information on gene and cellular therapy.

Klappentext

Molecular Cardiology for the Cardiologist, Second Edition provides a short, easily readable summary of what the new biology brings to cardiology. Special efforts have been made to include comprehensive diagrams and drawings, as well as teaching tables, and also to keep the size of the second edition within the modest limits of the first edition. The book remains divided into 5 parts. The first part is a general introduction to the new terminology. The second part is devoted to the normal structure of the heart and vessels. Parts 3 and 4 deal with physiopathology. One of the important contributions of molecular biology to cardiology is a better understanding of the general process of adaptation of the heart and vessels to a permanent mechanical overloading. Such a process is generally called remodeling, and results from coordinate changes in the expression of the genes. The last part of the book includes information on gene and cellular therapy.

Inhalt

1. The New Language Of Biology.- From Chromosome to Gene.- Current Technologies.- Gene Transfers.- Genome-Based Methods.- 2. The Normal Heart and Vessels. Molecular Structure in Relation to Physiology.- Membrane Proteins and Electrical Activity.- Sarcomere Structure and Contractility Cytoskeleton.- Extracellular Matrix and Tissue Compliance.- Vasoactive Endothelial Substances.- The Heart and Vessels As Endocrines.- Cardiac and Vascular Growth.- 3. Cardiac and Vascular Remodelling.- Cardiac Hypertrophy and Failure.- The Senescent Heart and Vessels.- 4. Genetics for Nongeneticians.- DNA Polymorphism.- Inherited Diseases.- Monogenic Cardiovascular Diseases.- Multigenic Cardiovascular Diseases and Risk Factors.- 5. Gene Therapy and Cell Transplant.- Gene therapy.- Vectors for gene transfer.- Gene transfer and cell transplant to repair MI.- Conclusion.- References.