Behavioral Neurobiology of Chronic Pain

Pain is the most common reason people seek medical help. The treatment of chronic pain is a major unmet clinical need and its impact on health, well-being, society and the economy is immense. Pain is an integrative, whole-systems (patho)physiological phenomenon and behavioural neuroscience plays a key role in advancing our understanding of pain. This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. Behavioural approaches to the study of persistent or chronic pain in animal models or humans are at the core of the volume, but the anatomical, physiological, neurochemical and molecular mechanisms that underpin behavioural alterations are also emphasized.

The focus on behavioral approaches to the study of chronic pain The emphasis on translational research and inclusion of work spanning preclinical and clinical A collection of world-leading authors never before assembled for a volume of this nature ? Includes supplementary material: sn.pub/extras

Klappentext

This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. It is essential reading for scientists, clinicians and students in need of a comprehensive review of behavioral readouts for the preclinical assessment of chronic pain and analgesic drug efficacy, or those with a general interest in behavioral neuroscience. At the core of this volume are emerging details of the physiology, pharmacology, and psychology of previously neglected types of chronic pain. These types include chronic post-operative pain in humans as well as animal behavioral assays that model the chronic pain of multiple sclerosis, post-herpetic neuralgia, painful diabetic neuropathy, visceral pain, latent central sensitization, and chronic muscle pain. Also emphasized are the complex bidirectional comorbidities between chronic pain and drug dependence, cognitive deficit, stress, anxiety, depression, social interaction, and prior injury history. The novel and exciting ideas introduced within this book, such as endogenous opioid dependence after tissue injury, generate real hope that effective treatment strategies for chronic pain will emerge in the near future.

Inhalt
Endogenous inhibition of pain behaviour.- Stress-induced hyperalgesia.- Pain and PTSD.- Chronic pain.- Behavior in children and juvenile.- Animal models.- Clinical chronic pain models.- Stress-induced analgesia.- Pain and cognition in multiple sclerosis.- Models of diabetesinduced neuropathic pain.- Operant conditioning of pain.- Post-herpetic neuralgia.- Chronic muscle pain.