This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

Systematically summarizing the cutting-edge knowledge in the study of autophagy Thoroughly discussing on the functions of autophagy in various diseases in major systems Serving as a critical reference tool for researchers and clinicians

Autorentext

Professor Weidong Le is a leading neurologist/neuroscientist with a focus on neurodegenerative diseases. He was a Professor of Neurology and Director of the Parkinson's Disease Research Center at Baylor College of Medicine, USA, and also served as a joint Professor and Director of the Institute of Neurology at Shanghai Jiao-tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. Since 2013, he has been the Vice President of the First Affiliated Hospital of Dalian Medical University and Director of Liaoning Provincial Center for Clinical Research on Neurological Diseases. He has published over 250 papers in Science, JAMA, Nature Genetics, Autophagy, Brain and Alzheimer's & Dementia and other international journals. He has been awarded 28 research grants, including 3 NIH R0-1 projects. He is a member of the review committee of NIH, VA, INSERM, Singapore Academy of Science, and the Chinese Nature Science Foundation. He is also the Section Editor of the Brain Research Bulletin, Associate Editor of the Neuroscience Bulletin, Journal of Alzheimer's Disease, and Cancer Medicine, and editorial board member of Autophagy, Alzheimer's Dementia, Translational Neurodegeneration and the Journal of Neurochemistry. Professor Le has been named by Elsevier publishing house as one of the "Most Cited Chinese Researchers" for 5 consecutive years, from 2014-2018.

Inhalt

Autophagy and Alzheimer's Disease.- Autophagy and Parkinson's Disease.- Autophagy and Motor Neuron Diseases.- Autophagy and Prion Disease.- Autophagy and Lysosome Storage Disorders.- Autophagy and Mitochondrial Encephalomyopathies.- Autophagy and Ischemic Stroke.- Autophagy and Hemorrhagic Stroke.- Autophagy and Polyglutamine Disease.- Autophagy and Epilepsy.- Autophagy in Neurodevelopmental Disorders.- Autophagy and Pituitary Adenoma.- Autophagy in Schizophrenia.- Autophagy and Hypertension.- Autophagy and Myocardial Ischemia.- Autophagy and Heart Failure.- Autophagy, Myocarditis and Cardiomyopathy.- Autophagy, Hyperlipidemia and Atherosclerosis.- Application of Autophagy in Cardiovascular Diseases.- Autophagy and Tumorigenesis.- Autophagy and Tumour Stem Cells.- Autophagy and Tumour Metastasis.- Autophagy and Tumor Cell Death.- Autophagy and Tumour Chemotherapy.- Autophagy and Tumour Radiotherapy.- Autophagy and Inflammatory Diseases.- Autophagy and Immune-related Diseases.- Autophagy and Autoimmune Diseases.- Autophagy and Bacterial Infection.- Autophagy and Viral Infection.- Autophagy and Thyroid Disease.- Autophagy and Obesity and Diabetes.- Autophagy and Obesity-related Reproductive Dysfunction.- Autophagy and Acute Kidney Injury.- Autophagy and Glomerular Diseases.- Autophagy and Diabetic Nephropathy.- Autophagy and Liver Diseases.- Autophagy and Gastrointestinal Diseases.- Chronic Obstructive Pulmonary Disease and Autophagy.- Autophagy and Pulmonary Fibrosis.- Asthma and Autophagy.- Autophagy and Other respiratory diseases.- Autophagy and Leukemia.- Autophagy and Lymphoma.- Autophagy and Myeloma.- The Function and Mechanisms of Autophagy in Traumatic Brain Injury.- The Function and Mechanisms of Autophagy in Spinal Cord Injury.- The Function and Mechanisms of Autophagy in Trauma of Other Parts of the Body.- The Prospects of Therapeutic Potential and Drug Development Targeting Autophagy in Cancer.- Progress of Anti-aging Drugs Targeting Autophagy.- Drug Development and Treatment of Autophagy in Other Diseases.- Systems Biology Approaches in Autophagy Research.- Natural Product Regulates Autophagy in Cancer.- Regulation of Autophagy in Neurodegenerative Diseases by Natural Products.- Regulation of Autophagy in Cardiovascular Diseases by Natural Products.