Over the past decade, molecular biology and genetics have brought great advances to our understanding of the mechanisms underlying auditory pathologies. This book presents recent developments in auditory research and their potential applications in clinical settings. In particular, the authors address the major dynamics of peripheral auditory trauma, including the underlying mechanisms, consequences to the central nervous system, protective interventions, and the possibility of restoring cochlear morphology and function. Two themes run throughout the chapters, cellular homeostasis and cell death. The book is of interest to scientists, audiologists, and clinicians who want to build their understanding of the pathology and treatment of hearing disorders. It is also recommended for biomedical and neuroscience researchers who want to learn the latest in the genetics and molecular biology of sensory pathology in the auditory system.

Brings together the basic and clinical sciences very nicely in that while most chapters are written by basic scientists, each topic has a pretty direct clinical application or implication Includes supplementary material: sn.pub/extras

Klappentext
The past decade has brought great advances in our understanding of the mechanisms underlying auditory pathologies. Molecular biology and genetics have primarily contributed to this enhanced understanding, which in turn has driven the design of novel rational therapeutic interventions. Auditory Trauma, Protection and Repair presents recent developments in auditory research and their potential translation to the clinical setting. In particular the authors address the major entities of peripheral auditory trauma, discuss the underlying mechanisms, the central nervous system consequences, protective interventions and finally explore the possibilities to restore cochlear morphology and function. Two themes run through the chapters in this book: cellular homeostasis and cell death. In the broadest sense, all auditory pathologies are disorders of cellular homeostasis. Contents: Auditory Pathology: When Hearing Is Out of Balance Jochen Schacht Genetics of Hearing Loss Ella Shalit and Karen B. Avraham Cochlear Homeostasis and Homeostatic Disorders Philine Wangemann Tinnitus: Theories, Mechanisms and Treatments Carol A. Bauer and Thomas J. Brozoski Autoimmune Inner Ear Disease Quinton Gopen, and Jeffrey P. Harris Age-Related Hearing loss and Its Cellular and Molecular Bases Kevin K. Ohlemiller and Robert D. Frisina The Patterns and Mechanisms of Noise-Induced Cochlear Pathology Donald Henderson, Bohua Hu, and Eric Bielefeld Drug-Induced Hearing Loss Leonard P. Rybak, Andrea E. Talaska, and Jochen Schacht Central Consequences of Cochlear Trauma D. Kent Morest andSteven J. Potashner Cell Death and Cochlear Protection Steven Green, Richard A. Altschuler, and Josef M. Miller Emerging Strategies for Restoring the Cochlea Stefan Heller and Yehoash Raphael About the editors: Jochen Schacht is Professor and Director of the Kresge Hearing Research Institute, University of Michigan, Ann Arbor. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago. About the series: The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.

Inhalt
Auditory Pathology: When Hearing is Out of Balance.- Genetics of Hearing Loss.- Cochlear Homeostasis and Homeostatic Disorders.- Tinnitus: Theories Mechanisms and Treatments.- Autoimmune Inner Ear Disease.- Age-Related Hearing Loss and Its Cellular and Molecular Bases.- Patterns and Mechanisms of Noise-Induced Cochlear Pathology.- Drug-Induced Hearing Loss.- Central Consequences of Cochlear Trauma.- Cell Death and Cochlear Protection.- Emerging Strategies for Restoring the Cochlea.