A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.

Includes supplementary material: sn.pub/extras

Klappentext

Despite an enormous amount of research in the past five years, our understanding of atypical parkinsonian disorders (APD) remains very much in its infancy. In Atypical Parkinsonian Disorders: Clinical and Research Aspects, a panel of highly knowledgeable and thoughtful investigators comprehensively reviews, for the first time, what is known not only about the cause and treatment of these devastating disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors focus on progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, dementia with Lewy bodies, and familial atypical parkinsonism, covering the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.
Comprehensive and authoritative, Atypical Parkinsonian Disorders: Clinical and Research Aspects will enable clinicians to better diagnose, treat, and provide ongoing support for their parkinsonian patients, as well as provide researchers from all fields with encouragement and focus to pursue new research directions.

Inhalt
What is an Atypical Parkinsonian Disorder?.- Historical Issues and Atypical Parkinsonian Disorders.- Epidemiology of Progessive Supranuclear Palsy and Multiple System Atrophy.- Neuropathology of Atypical Parkinsonian Disorders.- Animal Models of Tauopathies.- Neurodegenerative ?-Synucleinopathies.- Computer Modeling in Basal Ganglia Disorders.- Atypical Parkinsonian Disorders.- Genetics of Atypical Parkinsonism.- Medical History and Physical Examination in Parkinsonian Syndromes.- Role of Neuropsychiatric Assessment in Diagnosis and Research.- Added Value of the Neuropsychological Evaluation for Diagnosis and Research of Atypical Parkinsonian Disorders.- Role of Praxis in Diagnosis and Assessment.- Role of Visuospatial Cognition Assessment in the Diagnosis and Research of Atypical Parkinsonian Disorders.- Role of Ocular Motor Assessment in Diagnosis and Research.- Characterizing and Assessing Speech and Language Disturbances.- Quality of Life Assessment in Atypical Parkinsonian Disorders.- Progressive Supranuclear Palsy.- Corticobasal Degeneration.- Multiple System Atrophy.- Clinical Diagnosis of Dementia With Lewy Bodies.- Clinical Diagnosis of Familial Atypical Parkinsonian Disorders.- Clinical Diagnosis of Vascular Parkinsonism and Nondegenerative Atypical Parkinsonian Disorders.- Role of Electrophysiology in Diagnosis and Research in Atypical Parkinsonian Disorders.- Role of CT and MRI in Diagnosis and Research.- Role of Functional Magnetic Neuroimaging in Diagnosis and Research.- PET and SPECT Imaging in Atypical Parkinsonian Disorders.- Current and Future Therapeutic Approaches.- Rehabilitation of Patients With Atypical Parkinsonian Disorders.- Atypical Parkinsonism.