The present volume deals with drugs which play an important role in the therapy of schizophrenia. It describes the introduction of the first antipsychotics on the market and the importance of clozapine, a prototype for atypical antipsychotics, for further investigation of other potentially atypical antipsychotics, which may have an important impact on the therapy and especially the well being of schizophrenic patient

Inhalt
A general introduction.- to schizophrenia.- From first to second generation antipsychotics.- Animal models for schizophrenia: an introduction.- The preclinical evaluation of atypical antipsychotics.- Receptor profile of antipsychotics.- Regional selectivity of antipsychotic drugs.- Screening models for antipsychotic drugs.- Simulation models for schizophrenia.- The clinical evaluation of atypical antipsychotics.- Clozapine: the first atypical antipsychotic.- Dopamine receptor subtypes and schizophrenia: a clinical perspective.- Multireceptor atypical antipsychotic drugs.- New discoveries in the development of antipsychotics with novel mechanisms of action: beyond the atypical antipsychotics with serotonin dopamine antagonism.