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Asymmetric Catalysis

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Proceedings of the NATO Advanced Research Workshop on Asymmetric Catalysis, Sanibel Island, Florida, USA, January 2-6, 1984The rat... Weiterlesen
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Beschreibung

Proceedings of the NATO Advanced Research Workshop on Asymmetric Catalysis, Sanibel Island, Florida, USA, January 2-6, 1984

The rate of advance in areas of science is seldom constant. Usually certain fields effloresce with activity because of the ~ealization that solutions are possible to long standing important problems. So it is now with asymmetric catalysis, a field which promises to change profoundly the strategic thinking of synthetic chemists. As this Report will show, reagents which can induce catalytic enantiocontrol of chemical transformations could represent the ultimate synthetic method. Nearly all synthetic strategies of complex molecules involve steps which require enantiocontrol and, in many cases, a specific catalytic transformation embodying enan tiocontrol has enormous advantages in terms of the rate and economy of the reaction. Because asymmetric catalysis is in a formative stage, workers with different backgrounds have joined the field. This Workshop had representatives with organometallic, organic, structural, kinetic, enzymatic, microbiological and industrial backgrounds. Each had his own perspective and this Report represents a consensus of this group of eleven people. The result is probably as compre hensive and balanced a view of the subject as is possible at present. It is hoped that those who have until now had but a glancing interest in asymmetric catalysis will find this Report a useful indication of its present state. We believe that asymmetric catalysis will have an increasing impact on the development of chemistry and will eventually dominate much of synthetic and industrial chemistry.

Zusammenfassung
` ... presents an overview of the state of the art of this important subject (as of early 1984). It would be appropriate to any graduate level course in Organometallic, Catalytic, or Synthetic Chemistry. It would also serve as an selective primer for anyone considering serious research in this rapidly expanding field. '
Journal of the American Chemical Society, 108:18 (1986)


Inhalt
1 - General Principles.- 1. Catalysis.- 2. Turnover Limiting Step.- 3. Origin of Catalysis.- 4. Catalytic Cycles.- 5. Classification of Catalysts.- (a) Oxidative Addition-Reductive Elimination Catalysts.- (b) Single Oxidation State Activation Catalysts.- 6. Asymmetric Synthesis.- 7. Asymmetric Discrimination.- 8. Reactant Control and Product Control in the Enantio- selective Step.- References.- 2 - Carbon-Hydrogen Bond Formation.- 1. Asymmetric Catalytic Hydrogenation.- (a) Substrates.- (b) Phosphines.- (c) Results.- (d) Prospects.- (e) Mechanism of Asymmetric Hydrogenation.- (f) Kinetic Implications of Diastereomeric Equilibria.- (g) Product vs. Reactant Control of the Enantio- selective Step.- References.- 2. Asymmetric Hydrogenation of Ketones.- References.- 3. Asymmetric Double Bond Migration.- (a) Mechanisms.- (b) Examples.- References.- 4. Asymmetric Hydrosilation.- (a) Olefin Hydrosilation.- (b) Hydrosilation of Ketones.- (c) Hydrosilation of a, ?-unsaturated carbonyIs.- (d) Schiff Bases.- References.- 3 - Carbon-Carbon Bond Formation.- 1. Hydroformylation.- References.- 2. Asymmetric Hydrocarboxylation.- References.- 3. Asymmetric Hydrocyanation.- References.- 4. Asymmetric Allylic Alkylation.- (a) Mechanism of Allylation.- (b) Future Prospects.- References.- 5. Asymmetric Grignard Cross-Coupling.- References.- 6. Asymmetric Cyclopropanation.- (a) Introduction.- References.- 7. Catalytic Asymmetric Codimerization.- References.- 1. Catalytic Asymmetric Cyclodimerization, Skeletal Rearrangement and Telomerization and Asymmetric [3+2]-Cycloaddition.- References.- 2. Asymmetric Catalyzed Diels-Alder Reaction.- (a) Stoichiometric Enantiocontrol.- (i) Chiral Dienes.- (ii) Chiral Dienophiles.- (b) True Asymmetric Catalysis of Diels-Alder Reactions.- References.- 4 - Asymmetric Oxidation.- 1. Asymmetric Epoxidation.- References.- 2. Asymmetric Oxidation of Sulfides.- References.- 5 - Heterogeneous and Polymer Supported Catalysts.- 1. Impregnated Heterogeneous Catalysts.- 2. Electrochemical Asymmetric Reduction.- References.- 3. Polymer Supported Catalysts.- (i) Requirements.- (ii) Catalyst Preparation.- (iii) Asymmetric Synthesis.- (iv) Polymer Cooperative Effects.- References.- 6 - Asymmetric Catalysis by Biochemical Systems.- (i) Classification of Enzyme Reactions.- (ii) Coenzymes.- (iii) Fermentative vs. Enzymic Processes.- (iv) Enantiotopic Group Differentiation.- (v) Immobilized Enzymes and Cells.- (vi) Range of Applicability of Enzymes.- (a) Enantiotopic Face Discriminations.- (b) Enantiotopic Group Discriminations.- References.- 7 - Economic Significance of Asymmetric Catalysis.- 1. Economic Advantages of Asymmetric Synthesis.- 2. Intramolecular Aldol Condensations of Hajos and Eder.- References.- 3. Potential Chirons of Economic Importance.- (a) S-Malic and R-Malic Acids.- (b) S-Citramalic and R-Citramalic Acids.- (c) S-3- Hydroxyisobutyric Acid.- (d) S-(3-Pyridyl)ethanol.- 4. Examples of Target Molecules which have been more Economically Prepared by Asymmetric Synthesis.- 8 - Future Trends.- 1. Enzymes and Microbes.- 2. Inorganic Systems.- 3. Purely Organic Catalysts.- (a) Base-Catalyzed Reactions.- (b) Acid-Catalyzed Reactions.

Produktinformationen

Titel: Asymmetric Catalysis
Editor:
EAN: 9789401087919
ISBN: 9401087911
Format: Kartonierter Einband
Herausgeber: Springer Netherlands
Genre: Chemie
Anzahl Seiten: 172
Gewicht: 271g
Größe: H235mm x B155mm x T9mm
Jahr: 2011
Auflage: 1986

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