Arterial Chemoreceptors

The book will contain reviews and brief research articles from the participants attending the International Society for Arterial Chemoreception (ISAC) meeting, to be held in Lisbon in Portugal in June/July 2020. Since ISAC was first established, almost 70 years ago, many advances in the classical field of arterial O2, CO2 and pH sensing have been achieved but the most impressive ones are probably related to the non-canonical roles of the carotid body, as its involvement in sympatho-mediated diseases. Over the recent years, the carotid body field has gained attention with the findings that carotid body dysfunction is associated with the development/maintenance of highly prevalent diseases from cardio-metabolic diseases to asthma. Knowing that most of the patients with these pathologies lack long-term disease control, it is imperative to define new pathophysiological mechanisms aiming to find new therapeutic targets for treatment and prevention. This book will cover a broad range of topics related, not only with the fundamental knowledge of the mechanisms related with the chemical sensing in the carotid body, but also with the adaptive and mal-adaptive responses of arterial chemoreceptors to O2-dependent and O2-independent mechanisms, namely with their impact on respiratory, cardiovascular, and metabolic homeostasis in healthy and disease conditions. This volume will be required text for all the researchers in the field of arterial chemoreceptors and will provide a valuable reference source for years to come.

Autorentext

Dr. Silvia V. Conde is Professor of Pharmacology and Neuroscience and Principal Investigator at NOVA Medical School (NMS) . She graduated in Biochemistry in 2000 and has an Advanced Specialization Diploma in Physiology in 2005. As a PhD student under supervision of Prof. C. Gonzalez in Valladolid (Spain) and Emilia Monteiro (Portugal), she tried to understand how cells and the body respond to the lack of O2, through the study of the physiology of the carotid body. She pursued her PhD in Pharmacology from both the New University of Lisbon (Portugal) and the University of Valladolid (Spain) in 2007. Afterwards, she realized that for her the most exciting research involves trying to understand the pathophysiological alterations in the carotid body and in autonomic nervous system function that are in the genesis of cardiometabolic and respiratory Human diseases. As a PI, she developed a new line of research on the carotid body (CB) and dysmetabolism, which is based on the pioneering idea that the CB controls glucose homeostasis. She is dedicated to the characterization of pathophysiological biosignals, disease signatures and fingerprints that will allow the identification of targets for therapy, particularly bioelectronic targets, as her group recently described that high frequency electrical stimulation of carotid sinus nerve restores insulin sensitivity and glucose homeostasis in type 2 diabetes models. Her research in this field originated 2 patents, being one already licensed.

In 2009 she was awarded with the L'Oreal Medals Honor for Women in Science Portugal and since then her group won several prizes from the Portuguese Society of Diabetes and from the Pulido Valente Foundation. Silvia V. Conde lab is funded by grants from the Portuguese Funding Agency (Fundação para a Ciência e Tecnologia) and from Galvani Bioelectronics.

Dr. Rodrigo Iturriaga obtained the degree of Doctor in Physiological Sciences, at the P. Catholic University of Chile (1988) and subsequently made a postdoctoral stay in the Department of Physiology of the University of Pennsylvania, USA (1989-1992). He began his academic career as an Assistant Professor in the Department of Physiology of the Faculty of Biological Sciences of the P. Universidad Católica de Chile (1992), where he is currently Full Professor and Chairman. He teach physiology medical students and PhD. postgraduate in of the Faculty of Biological Sciences of the P Catholic University, where he has directed the doctoral theses of 12 graduates. His area of interest is the neurobiology of arterial chemoreceptors and his participation in the physiological and pathological responses induced by intermittent hypoxia. He is the author of more than 130 ISI publications and book chapters. He received the John F. Perkins Jr. Memorial Fellowship Award, from the American Physiological Society, USA (1989), the Francis B. Parker Fellowship for postgraduate studies in Respiratory Physiology, USA(1992), the Young Scientists Reintegration Scholarship of the Andes Foundation (1992), the Ferdinando Data Foundation Incentive Award for Young Researcher in Arterial Chemoreception, of the International Society for Arterial Chemoreception (1993) and the 2008 teaching excellence award from the P. Universidad Católica de Chile. He is a member of several scientific societies including the American Physiological Society, the Society for Neuroscience, Sociedad Española de Ciencias Fisiologicas and Sociedad Chilena de Ciencias Fisiologicas.

Dr. Rodrigo Del Rio is Professor of Physiology at the Biological Sciences Faculty of the Pontificia Universidad Católica de Chile. He obtained his graduate degree in Physiology under the supervision of Dr. Rodrigo Iturriaga and then travel overseas to the United States of America, to be trained as a Postdoctoral Fellow in the area of neural control of cardiovascular and respiratory regulation at the University of Nebraska Medical Center und

Inhalt
Preface.- Chapter 1. Transcriptomics of the carotid body (Audrys G. Pauza, David Murphy and Julian F. R. Paton).- Chapter 2. The adult carotid body: a germinal niche at the service of physiology (Ricardo Pardal).- Chapter 3. Evidences that sympathetic overactivity and neurogenic hypertension correlate with changes in the respiratory pattern in rodent models of experimental hypoxia (Benedito H. Machado).- Chapter 4. Control of arterial hypertension by the AhR blocker CH-223191: a chronopharmacological study in chronic intermittent hypoxia conditions (António B. Pimpão, Cátia Sousa, Maria J. Correia, Nuno R. Coelho, Emília Monteiro, António F. Melo Júnior and Sofia A. Pereira).- Chapter 5. Three days of chronic intermittent hypoxia induces 1-adrenoceptor dependent increases in left ventricular contractility (Anthony L. Marullo, Eric F. Lucking, Daniel Pender, Pardeep Dhaliwal and Ken D. O'Halloran).- Chapter 6. The beneficial effect of the blockade of stim-activated TRPC-ORAI channels on vascular remodeling and pulmonary hypertension inducedby intermittent hypoxia is independent of oxidative stress (Rodrigo Iturriaga and Sebastián Castillo-Galán).- Chapter 7. Intermittent hypoxia and weight loss: insights into etiology of the sleep apnea phenotype (Marianne Gagnon, Stéphanie Fournier, François Marcouiller, Loralie Guay, Vincent Joseph, Natalie J Michael and Richard Kinkead).- Chapter 8. Effects of gestational intermittent hypoxia on placental morphology andfetal development in a murine model of sleep apnea (Esther Valverde-Pérez, Jesús Prieto-Lloret, Elvira Gonzalez-Obeso, María I. Cabero, Maria L. Nieto, Marta I. Pablos, Ana Obeso, Angela Gomez-Niño, Rosa M. Cárdaba-García, Asunción Rocher and Elena Olea).- Chapter 9. Ventilatory effects of acute intermittent hypoxia in conscious dystrophic mice (Michael N. Maxwell, Anthony L. Marullo, Aoife D. Slyne, Eric F. Lucking and Ken D. O'Halloran).- Chapter 10. Intermittent hypoxia and diet-induced obesity on the intestinalwall morphology in a murine model of sleep apnoea (Esther Valverde-Pérez, Elena Olea, Ana Obeso, Jesús Prieto-Lloret, Asunción Rocher and Elvira Gonzalez-Obeso).- Chapter 11. Enhanced peripheral chemoreflex drive is associated with cardiorespiratory disorders in mice with coronary heart disease (Liena Bravo, Katherin V. Pereyra, Hugo S. Diaz, Mariajosé Flores, Karla G. Schwarz, Camilo Toledo, Esteban Díaz-Jara, Leticia González, Marcelo E. Andia …