There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late onset Alzheimer's disease, the common form of the disease defined as starting after 60 years of age. The roles of apolipoprotein E in normal brain metabo lism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This is why the Fondation Ipsen organised an interna tional meeting on this topic in Paris on May 29,1995, and the proceedings are contained in this book. The editors wish to thank Mrs Mary Lynn Gage for editorial and Mrs Jacqueline Mervaillie for the organization of the meeting in Paris. Allen Roses Karl Weisgraber Yves Christen Contents Apolipoprotein E and Alzheimer's Disease: State of the Field After Two Years A. D. Roses, W. I. Strittmatter, A. M. Saunders, D. E. Schmechel, and M. A. Pericak-Vance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Role of Apolipoprotein E in Alzheimer's Disease: Clues from its Structure KH. Weisgraber and L. M Dong . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Apolipoprotein E4, Cholinergic Integrity, Synaptic Plasticity and Alzheimer's Disease I. Poirier, M-C. Delisle, R. Quirion, I. Aubert, I. Rocheford, I. Rousse, S. Gracon, M. Farlow, and S. Gauthier. . . . . . . . . . . . . . . . . . . 20 Pattern of Apolipoprotein E Immunoreactivity During Brain Aging D. E. Schmechel, MO. Tiller, P. Tong, M McSwain, S. -H. Han, R. Ange, D. S. Burkhart, and MK Izard. . . . . . . . . . . . . . . . . . . . . . . . . . .

Inhalt
Apolipoprotein E and Alzheimer's Disease: State of the Field After Two Years.- Role of Apolipoprotein E in Alzheimer's Disease: Clues from its Structure.- Apolipoprotein E4, Cholinergic Integrity, Synaptic Plasticity and Alzheimer's Disease.- Pattern of Apolipoprotein E Immunoreactivity During Brain Aging.- Apolipoprotein E: Structure, Function, and Possible Roles in Modulating Neurite Extension and Cytoskeletal Activity.- Apolipoprotein E Role in Maintaining the Integrity of the Aging Central Nervous System.- Very Low Density Lipoprotein Receptor and Alzheimer's Disease.- Apolipoprotein E and Apolipoprotein E Receptors in the Central Nervous System: Relationship with Alzheimer's Disease.- Tau Protein and the Neurofibrillary Pathology of Alzheimer's Disease.- Tau Protein and Alzheimer Paired Helical Filament Assembly: Interacting Domains and Control Residues.- The ßA4 Amyloid Peptide Enhances Cellular Uptake of Apolipoprotein E-Containing Lipoproteins by the Low-Density Lipoprotein Receptor-Related Protein/?2-Macroglobulin Receptor.- Interactions of Apolipoprotein E with Microtubule-Associated Proteins.- Chaperoning Amyloid in Alzheimer's Disease: The Art of Avoiding Sticky Situations?.- Apolipoprotein E Oxidation and Functional Consequences.- Ethnic Variation in the Association Between APOE-?4 and Alzheimer's Disease: A Follow-up Study.- The Search for Additional Alzheimer's Disease Genes.