This volume is part of a comprehensive reference covering antimicrobial drug resistance in bacteria, fungi, viruses, and parasites. It covers the biological basis of drug resistance and effective avenues for drug development.

This ? rst edition of Antimicrobial Drug Resistance grew out of a desire by the editors and authors to have a comprehensive resource of information on antimicrobial drug resistance that encompassed the current information available for bacteria, fungi, protozoa and viruses. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students and fellows in training. We have endeavored to provide this information in a style which would be accessible to the broad community of persons who are concerned with the impact of drug resistance in our cl- ics and across the broader global communities. Antimicrobial Drug Resistance is divided into Volume 1 which has sections covering a general overview of drug resistance and mechanisms of drug resistance ? rst for classes of drugs and then by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci? c drug resistance assays. Together, these two volumes offer a comprehensive source of information on drug resistance issues by the experts in each topic.

From the reviews: This weighty tome provides a series of reviews by internationally respected authors, including Drs Baquero, Bush, LeClercq, Jacoby and many more. Overall, a worthwhile reference work for institutional libraries and for scientists with broad interests in the field of resistance. (David Livermore, Microbiology Today, January, 2010)

Klappentext

The volumes included in Antimicrobial Drug Resistance represent the first comprehensive, multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives.

The first volume, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance , is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant strains, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of currently available ones.

The second volume, Antimicrobial Drug Resistance, Clinical and Epidemiological Aspects , is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious disease physician requires input from the clinical microbiologist and infection control specialist to make informed choices for the effective treatment of various strains of drug-resistant pathogens in individual patients.

This 2-volume set is an important reference for students in microbiology, infectious disease physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.

Inhalt
General Overview.- History of Drug-Resistant Microbes.- Evolutionary Biology of Drug Resistance.- Pharmacology of Drug Resistance.- Antimicrobial Resistance Versus the Discovery and Development of New Antimicrobials.- General Mechanisms of Drug Resistance.- Genetic Mechanisms of Transfer of Drug Resistance.- Mutations as a Basis of Antimicrobial Resistance.- Target-Mediated Antibacterial Resistance.- Biochemical Logic of Antibiotic Inactivation and Modification.- Antibiotic Resistance Due to Reduced Uptake.- Transport Mechanisms of Resistance to Drugs and Toxic Metals.- The Functional Resistance of Bacterial Biofilms.- Bacterial Drug Resistance Mechanisms.- The Importance of ?-Lactamases to the Development of New ?-Lactams.- Penicillin-Binding Proteins and ?-Lactam Resistance.- Aminoglycosides: Mechanisms of Action and Resistance.- Tetracycline and Chloramphenicol Resistance Mechanisms.- Fluoroquinolone Resistance in Bacteria.- Plasmid-Mediated Quinolone Resistance.- Macrolides and Lincosamides.- Mechanism of Resistance in Metronidazole.- Glycopeptide Resistance in Enterococci.- Streptogramin.- Resistance to Linezolid.- Sulfonamides and Trimethoprim.- Mechanisms of Action and Resistance of Antimycobacterial Agents.- Fungal Drug Resistance Mechanisms.- Amphotericin B: Polyene Resistance Mechanisms.- Fungal Drug Resistance: Azoles.- Flucytosine: Site of Action, Mechanism of Resistance and Use in Combination Therapy.- Echinocandins: Exploring Susceptibility and Resistance.- Antifungal Targets, Mechanisms of Action, and Resistance in Candida albicans.- Viral Drug Resistance Mechanisms.- Mechanisms of Resistance of Antiviral Drugs Active Against the Human Herpes Viruses.- Influenza M2 Ion-Channel and Neuraminidase Inhibitors.- Molecular Mechanisms ofResistance to Nucleoside Reverse Transcriptase Inhibitors.- Resistance to HIV Non-Nucleoside Reverse Transcriptase Inhibitors.- Resistance to HIV-1 Protease Inhibitors.- Resistance to Enfuvirtide and Other HIV Entry Inhibitors.- Resistance to Inhibitors of Human Immunodeficiency Virus Type I Integration.- The Hepatitis B Virus and Antiviral Drug Resistance: Causes, Patterns, and Mechanisms.- Mechanisms of Hepatitis C Virus Drug Resistance.- Parasitic Drug Resistance Mechanisms.- Drug Resistance Mechanisms in Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Opportunistic Anaerobic Protozoa.- Mechanisms of Antimalarial Drug Resistance.- Drug Resistance in Leishmania.- Drug Resistance in African Trypanosomiasis.- Drug Resistance and Emerging Targets in the Opportunistic Pathogens Toxoplasma gondii and Cryptosporidium parvum.- Drug Resistance in Nematodes.- Chemotherapy and Drug Resistance in Schistosomiasis,Fascioliasis and Tapeworm Infections.- Drug Resistance in Ectoparasites of Medical and Veterinary Importance.