This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory.
Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

Explores novel approaches for the development of antiepileptic therapies to combat pharmacoresistance Features practical guidance for the implementation of important protocols Serves as an ideal source for medicinal chemists, pharmacologists, and other researchers working in the field Includes supplementary material: sn.pub/extras

Inhalt

Inflammatory Cytokines as Targets for Epilepsy Drug Therapy.- The Use of Anti-Inflammatory Drugs in Epilepsy.- Carbonic Anhydrase and Epilepsy.- Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs.- Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?.- Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy.- Neurosteroid Regulation of Seizures: Role of GABA A Receptor Plasticity.- Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy.- Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery.- Gene Therapy in Epilepsy.- Human Brain Tissue as a Model for the Study of Epilepsy.- The Blood-Brain Barrier and the Design of New Antiepileptic Drugs.- Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates.- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations.- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations.- Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies.- Side Effects of Antiepileptic Drugs.- Network Pharmacology and Epilepsy.- The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development.