This textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting out-of-the-box thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health.

This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms.

Written in a vivid and easy-to-understand manner Advocates a conceptual and integrated approach to understanding bacteria and the diseases they cause Provides explanatory illustrations of the main concepts

Autorentext

Dr. Anthony William Maresso, Ph.D., is a Professor and Scientist at Baylor College of Medicine in Houston, Texas. His research aims to understand how bacteria cause disease in their human hosts so as to discover and develop preventative vaccines and therapies for deadly infections.

Inhalt

1. A Short History of Microbiology.- 2. The Form and Function of a Bacterial Cell.- 3. The Practice of the Microbe Hunter.- 4. Innate Immunological Defenses against Bacterial Attack.- 5. Adaptive Immunological Defenses against Bacterial Attack.- 6. The Mutagenic Tetrasect7. Bacterial Bindance: Adhesins and their Engagement to Host.- 8. Bacterial Invasion of the Host Cell.- 9. Bacterial Secretion Systems.- 10. Bacterial Protein Toxins and Effectors.- 11. The Acquisition and Consumption of Host Nutrients.-12. Biofilms.- 13. The Human Microbiome.- 14. Sepsis.- 15. Bacterial Vaccines and the Challenges Ahead.- 16. Antibiotics and their destruction.