Animal cell technology is a newly growing discipline of cell biology which aims not only to understand structure, function and behavior of differentiated animal cells but also to uncover their ability useful for industrial and medical purpose. The goal of animal cell technology includes clonal expansion of differentiated cells with useful ability, optimization of their culturing in industrial scale, modulation of their ability for production of pharmaceutical proteins and monoclonal antibodies, and newly application to gene therapy and organ culture. The last seven Annual Meetings of the Japanese Association for Animal Cell Technology (JAACT) had attracted increasing number of participants. At the Eighth Meeting (JAACT'95) held in Iizuka from November 6 through 10, 1995. Before this Meeting, we were all shocked by the sudden death of a founder of JAACT, the late Prof. Hiroki Murakami in February of this year. But we had more than 90 participants from outside of Japan and 170 from Japan in this Meeting. The editors express their sincere gratitude to all researchers who joined the meeting, to the organizers of the Symposium Sessions, to members of the organizing committee who dedicated themselves in assuring the Meeting's success in the absence of Prof. H. Murakami, and the graduates and undergraduates students of Kyushu University and Kyushu Institute of Technology who supported management of the Meeting. We also thank the Japanese Bioindustry Association and Fukuoka Science & Technology Foundation for the financial support.

Klappentext

Animal Cell Technology is a growing discipline of cell biology which aims not only to understand the structure, function and behavior of differentiated animal cells but also to ascertain their usefulness for industrial and medical purposes. The goal of animal cell technology includes clonal expansion of differentiated cells for practical applications, optimization of their culturing on an industrial scale, modulation of their ability for production of pharmaceutical proteins and monoclonal antibodies, and application to gene therapy and organ culture. This volume gives a complete review of the state-of-the-art in Japan, a country where this field is particularly well advanced. This book should be of interest to cell biologists, biochemists, molecular biologists, biochemical engineers and other disciplines related to animal cell culture, working in the academic environment, as well as in the biotechnology or pharmaceutical industry.

Inhalt
Preface. Symposium 1. Advance in Animal Cell Technology - Memories of Late Prof. Hiroki Murakami. Symposium 2. Cell Culture for Cell Therapy Application. Symposium 3. Modeling and Control of Animal Cell Culture. Symposium 4. Process Analysis of Animal Cell Culture. Symposium 5. Glycosylation-Based Biotechnology. Symposium 6. Application of Human Monoclonal Antibodies; Production, Characterization and Clinical Experience. Symposium 7. Hydrodynamics and Mass Transfer in Animal Cell Culture. Symposium 8. Information and Animal Cell. Symposium 9. Human Tissue Resources: Past, Present and Future. Symposium 10. Apoptosis. Mini Symposium. Tissue Engineering. Symposium Extra. Gene Therapy. I. Serum and Protein Free Culture. II. Cell Physiology for Enhancing Productivity. III. Animal Cell Bioreactors and High Density Culture. IV. Cell Culture Engineering. V. Glycoengineering for Enhancing in vivo Activities. VI. Cell Culture Engineering for Artificial Organs. VII. Expression of Recombinant Animal Genes in Cultured Animal Cells. VIII. Biological Properties of Proteins Produced by Animal Cells. IX. Apoptosis. X. Application of Human Monoclonal Antibody. XI. Animal Cell Culture for Medical and Clinical Use. XII. Transgenic Animals for Production of Biomedicals and Foods. XIII. In vitro Assay Systems for Environmental Hazards and for Replacement of Experimental Animals. XIV. Cell Culture for Assessment of Physiologically Functional Substances in Food and Natural Resources. XV. Cell Characterization and Validation. Author Index. Subject Index.