Angiogenesis in Inflammation: Mechanisms and Clinical Correlates

Angiogenesis is an essential component of inflammation and its resolution. Traditionally, mechanisms of angiogenesis in inflammation were inferred from tumour angiogenesis. However, research in recent years has extracted the similarities and dissimilarities between these processes.

This volume shows how the lessons learned from tumour biology have been applied to inflammation. It develops current knowledge on molecular and cellular mechanisms as they relate to inflammation, including acute and chronic inflammation and neurogenic inflammation, It explains the roles of the multiple cellular components of inflammation, such as fibroblasts, dendritic cells and lymphocytes.

The book shows how this knowledge is being used in the discovery of novel therapeutics. It brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and human disease.

Links the molecular and cellular processes in angiogenesis to those of inflammation and disease Written by leading experts in the field International authorship Includes supplementary material: sn.pub/extras

Klappentext

Angiogenesis is an essential component of inflammation and its resolution. This volume provides up-to-date information on the latest developments in the pathology, mechanisms and therapy of angiogenesis dependent inflammatory disease. Recent years have seen large advances in angiogenesis research, especially in oncology. Traditionally mechanisms in inflammation angiogenesis were inferred from tumour angiogenesis, however recent research has matured highlighting the similarities and dissimilarities between these processes. This volume relates the lessons learned from tumour biology applied to inflammation.

This issue of Angiogenesis in Inflammation: Mechanisms and Clinical Correlates develops current knowledge on the mechanisms at the molecular and cellular levels as they relate to inflammation, including acute and chronic inflammation, neurogenic initiation, and the role of the multiple cellular components that comprise inflammation: granulocytes, macrophages, fibroblasts, dendritic cells and lymphocytes. This is related to inflammatory disease: not only the familiar angiogenesis dependent diseases of rheumatoid arthritis and psoriasis, but also loci such as the lung, gastric ulcers, the eye with uveitis, wound healing and periodontal disease and their therapy, how this knowledge may be used in the discovery of novel therapeutics. The volume brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and disease, culminating in a discourse on areas for future therapies.

Inhalt
Neurogenic angiogenesis and inflammation.- The angiogenic drive in chronic inflammation: Hypoxia and the cytokine milieu.- Dendritic cells and angiogenesis.- The lymphocyte in inflammatory angiogenesis.- The fibroblast and myofibroblast in inflammatory angiogenesis.- Chemokines and cytokines in inflammatory angiogenesis.- Modelling angiogenesis in inflammation.- Angiogenesis in the inflammation of arthritis.