Alzheimer's disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer's Disease: A Physician's Guide to Practical Management was written by selected clinicians and scientists who represent some of the world's leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.

Includes supplementary material: sn.pub/extras

Klappentext
Alzheimer's disease (AD) is not only affecting increasingly large numbers of elderly and even middle-aged people in a worldwide epidemic, but also appears to be under-diagnosed and under-treated. In Alzheimer's Disease: A Physician's Guide to Practical Management, clinicians, scientists, and opinion leaders from all over the world provide a concise practical guide to the evaluation, assessment, and treatment of individuals with probable AD, illuminating the basic biology underlying the disease and outlining the many emerging therapeutic as well as promising preventive directions. On the clinical side, the authors focus on such issues as early changes and preclinical conditions-including mild cognitive impairment and predementia AD-how the patient presents, the state-of-the-art therapy, and the recent neuropsychiatric aspects of AD. Late-life issues are discussed, as well as the treatment of frequent comorbidities and the often-neglected dental care. On the practical side, guidance is offered to medical providers and caregivers on the deep feelings of isolation, loneliness, and despair that the illness can create in caregivers, and on how to overcome the consequent breakdown in communication with the patient. The authors also provide a comprehensible account of our current understanding of AD, as well as intriguing future strategies for its prevention and treatment, including stem cell therapy.
Comprehensive and practical, Alzheimer's Disease: A Physician's Guide to Practical Management not only offers physicians, caregivers, and all interested lay people a readable future-oriented overview of the disease, but also bridges the gap between basic science and the everyday challenges of treating and managing AD patients.

Inhalt
1 Genetics of Alzheimer's Disease and Related Disorders.- 2 Neuropathology of Alzheimer's Disease.- 3 Oxidative Stress in the Development of Alzheimer's Disease and Other Dementias.- 4 Metabolism and Alzheimer's Disease.- 5 Alzheimer's Disease: Epidemiological and Statistical Data.- 6 The Economic Burden of Alzheimer's Disease and Dementia.- 7 Potential and Established Risk Factors for Alzheimer's Disease.- 8 Medical Diagnosis and Workup of Alzheimer's Disease.- 9 Neuroimaging Techniques: CT, MRI, SPECT, PET.- 10 Biological Markers in Alzheimer's Disease.- 11 The Neuropsychology of Alzheimer's Disease.- 12 Vascular Cognitive Impairment in Clinical Practice.- 13 Lewy Body Disease.- 14 Frontotemporal Lobe Dementia.- 15 Mild Forgetfulness: Distinguishing Early AD from Normal Aging.- 16 Mild Cognitive Impairment: What the Physician Should Know.- 17 Diagnosis of Predementia AD in a Clinical Setting.- 18 Loss of Olfactory Function in Patients With Alzheimer's Disease.- 19 Treatment of Alzheimer's Disease: Basic Considerations.- 20 Donepezil in Treatment of AD.- 21 Rivastigmine for Treatment of AD.- 22 Galantamine in Treatment of AD.- 23 Memantine in Treatment of AD.- 24 Alternative Treatment Options.- 25 Pain and Palliative Care in Late-Stage Dementia Patients.- 26 Cardiological Issues in Late-Stage Alzheimer's Disease: A Clinician's Approach.- 27 Neuroprotection and Neurodegenerative Disease.- 28 Neurotrophic Factors for Prevention of Alzheimer's Disease.- 29 Statins in Prevention and Treatment of Alzheimer's Disease.- 30 Potential Role of Androgens and Androgen Receptors in Alzheimer's Disease.- 31 Role of Nutrition in Prevention or Delay of Alzheimer's Disease.- 32 Impact of Physical Activity on Prevention of Alzheimer's Disease.- 33Stem Cell Therapy for Alzheimer's Disease.- 34 Secretases as Potential Targets for Treatment of Alzheimer's Disease.- 35 AMPA Potentiation as a Treatment Option for Alzheimer's Disease.- 36 Glycosaminoglycans as Potential Future Treatment of Alzheimer's Disease.- 37 Implications of Research for Management of AD.- 38 Rating Scales and Outcome Variables Used in Clinical Trials.- 39 Gender Differences in Behavior of AD Patients.- 40 Management of Emotional and Behavioral Symptoms in AD.- 41 Assessment and Treatment of Neuropsychiatric Symptoms in Alzheimer's Disease.- 42 Neuropsychiatric Symptoms in African American Dementia Patients.- 43 Resource Utilization by African American Dementia Patients.- 44 Apathy in Alzheimer's Disease: Relationship to Executive Function.- 45 Are Alzheimer's Patients Aware of Their Deficits?.- 46 Diagnostic Family Conference in AD: Issues and Recommendations.- 47 Care, Caregiver Issues, and Communication With the Demented Patient.- 48 Dental Care of AD Patients.- 49 Long-Term Medical Care Issues.- 50 Loneliness and Depression in Caregivers.- 51 Frequently Asked Questions About Alzheimer's Disease.