This volume gives the pathomechanisms of various allergic diseases and their classification, including such important special aspects as allergy and bone marrow, allergy and the nervous system, and allergy and mucosal immunology.

When I entered the field of allergy in the early 1970s, the standard textbook was a few hundred pages, and the specialty was so compact that texts were often authored entirely by a single individual and were never larger than one volume. Compare this with Allergy Frontiers: Epigenetics, Allergens, and Risk Factors, the present s- volume text with well over 150 contributors from throughout the world. This book captures the explosive growth of our specialty since the single-author textbooks referred to above. The unprecedented format of this work lies in its meticulous attention to detail yet comprehensive scope. For example, great detail is seen in manuscripts dealing with topics such as Exosomes, naturally occurring minimal antigen presenting units and Neuropeptide S receptor 1 (NPSR1), an asthma susceptibility gene. The scope is exemplified by the unique approach to disease entities normally dealt with in a single chapter in most texts. For example, anaphylaxis, a topic u- ally confined to one chapter in most textbooks, is given five chapters in Allergy Frontiers. This approach allows the text to employ multiple contributors for a single topic, giving the reader the advantage of being introduced to more than one vi- point regarding a single disease.

Includes supplementary material: sn.pub/extras

Autorentext
Prof. Stephen Holgate, MRC Clinical Professor of Immunopharmacology, Division of Respiratory Cell and Molecular Biology, University of Southhampton School of Medicine. Applying basic science to the clinical interface in allergy and asthma has been the guiding principle of Prof. Stephen Holgate's career. This has involved him in environmental and genetic epidemiology, physiology, cell and molecular biology of disease processes as they occur in humans. An AAAAI member since 1986 and Fellow from 1993, Professor Holgate has been active in the field of allergy and immunology both in the United Kingdom and overseas and in 2001 received the Academy's Honorary Fellow Award. He was President of the British Society of Allergy and Clinical Immunology (BSACI) from 1990-93 and the Robert Cook Memorial Lecturer in 1995 and 2000. He received the RCP London Graham Bull Prize for research and was elected an honorary member of the Association of Physicians in UK and Ireland following the delivery of the Sir William Osler Lecture in 2003. He has been an active contributor to the Collegium Internationale Allergologicum since 1990. Professor Holgate is a member of the Infection, Inflammation and Repair Division in the School of Medicine, University of Southampton at Southampton General Hospital, UK and since 1987 has held a Medical Research Council (MRC) Clinical Professorship. He received his undergraduate medical training at Charing Cross Hospital, London and specialised in respiratory medicine and allergy. He holds Fellowships from the Royal Colleges of Physicians, Pathologists, Institute of Biology and Academy of Medical Sciences. He is a member of the Royal Commission on Environmental Pollution and has been a censor of the Royal College of Physicians. He has served on a number of Government Committees including the Sub-committee for Efficacy and Adverse Drug Reactions of the CSM (SEAR), MRC Project Grant Committee, Systems Board, Cross Board Group and most recently Councils Subcommittee on Corporate Policy and Evaluation (SCoPE), its Clinical Research Oversight Group (CROG) and is Chairman of Councils new Subcommittee on Evaluation (SOE). He has been Chairman of the UK Department of Health Committee on the Medical Effects of Air Pollution and has been appointed as Chairman of the UK Government (DEFA) Expert Panel on Air Quality Standards and Chairman of the Science Council's Science in Health Group. He has been a member of the Royal Commission of Environmental Pollution since 2002. He serves as a member of the Board of Directors for the World Allergy Organization (WAO). Professor Holgate's wwork has been recognised with a Scientific Achievement Award of the IAACI in 1994, the Rhone-Poulenc Rorer World Health Award in 1995, the King Faisal International Prize in Medicine in 1999 and Doctorates Hon Causa at University of Ferrara, Italy and Jagellonian University, Krakow, Poland in 1997 and 1999 respectively. He was elected to the Polish Academy of Arts and Science in 2001, received the Royal Society of Medicine Ellison Cliffe Medal in 2003 and the University of Ghent Gold Medal for Achievement in Clinical Science in 2004. According to the ISI Prof. Holgate was 8th most frequently cited author between 1990-2000 in the field of Biomedical Sciences in the United Kingdom and in 2002 became a member of ISI's most highly cited researcher databas.

Inhalt
Classification and Pathomechanisms.- Basic Aspects of Allergy and Hypersensitivity Reactions.- Pathogen Recognition and New Insights into Innate Immunity.- New Nomenclature and Clinical Aspects of Allergic Diseases.- IgE and the High-Affinity Receptor, Fc?RI: The IgE-CD23 Interaction.- Superantigens and Allergic Disease.- Immune Complexes: Normal Physiology and Role in Disease.- What Is New About Eosinophil Activation in Asthma and Allergic Disease.- Mast Cell and Basophils: Interaction with IgE and Responses to Toll like Receptor Activators.- T Cells in Allergic Disease.- Role of NKT Cells in the Regulation of Ongoing Type 2 Immune Response.- CD8+ T Cells Play a Key Role in the Development of Allergic Lung Inflammation.- Neutrophils and Their Mediators in Asthma and Allergic Disease.- Dendritic Cells, Macrophages and Monocytes in Allergic Disease.- Function of Dendritic Cell Subsets in Allergic Disease.- Epithelial Cell-Mesenchymal Interaction, Epithelial-Leukocyte Interaction and Epithelial Immune-Response Genes in Allergic Disease.- Role of Epidermal Growth Factor Receptor Cascade in Airway Epithelial Regulation of Mucus Production.- Epithelial Cell Innate Responses to Rhinovirus Infection.- The Role of Platelets in Allergy.- Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells.- Effects of Nitric Oxide on Mast Cells: Production, Functions, and Mechanisms of Action.- Histamine and Its Receptors.- Adenosine: Its Contribution to Our Understanding in Airway Inflammation.- Airway Smooth Muscle Dysfunction in Asthma.- Genetic Variation in Cytokines, Asthma, and Atopy: The Role of IL-4/IL-13 Pathway Polymorphisms.- Allergy and the Bone Marrow: Transmigration Pathways of Hemopoietic Progenitor Cells from the Bone Marrow.- HemopoieticMechanisms in Allergic Rhinitis and Asthma.- Allergy and the Nervous System.- Neuroanatomy of the Airways.- Biology of Neurotrophins, Neuropeptides, and Muscarinic Receptors in Asthma.- Neural Regulation of the Immune Response.- Neuroregulation of Mucosal Vasculature.- Allergy and Mucosal Immunology.- Mucosal Immunity: from Allergy to Coeliac Disease.- Mucosa-Associated Lymphoid Tissue and Dynamics of Lymphoid Cells in the Five Different Compartments in Allergic Diseases.