A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

Includes supplementary material: sn.pub/extras

Klappentext
Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidosis, HIV-associated dementia, and HTLV-associated neurological disorders.
Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS conditions and the emerging diagnostic and therapeutic opportunities they provide.

Inhalt
Endothelial Cell-Leukocyte Interactions During CNS Inflammation.- Multiple Sclerosis.- Cytokines and Brain.- Chemokines and Central Nervous System Disorders.- Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders.- Multiple Sclerosis.- Neuroprotective Effects of Interferon-? in Multiple Sclerosis.- Acute Disseminated Encephalomyelitis.- Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis.- Neuromyelitis Optica.- Transverse Myelitis.- Optic Neuritis.- Central Nervous System Vasculitis.- Neurosarcoidosis.- Neuropsychiatric SLE.- Gene Expression in HIV-Associated Dementia.- Human T-Lymphotropic Virus-Associated Neurological Disorders.- West Nile Virus Infection of the Nervous System.