The author's general aim has been to survey as wide a field of evidence as possible and this had involved excursions into subjects of which he has little first hand knowledge. This width of range also has necessitated a somewhat arbitrary selection of evidence and has prevented full discussion of any indi vidual problem. The author trusts that he has not misrepresented anyone's results or opinions, and if this has occurred, he can only plead in excuse the peculiar difficulty of giving a brief and yet accurate account of evidence of such a wide variety. The diagrams reproduced in the article have all been redrawn and in many cases the original figures or diagrams have been modified as, for instance, by recalculating dosage on the logarithmic scale. The original authors therefore have no direct responsibility for the diagrams in their present form. The author desires to thank Messrs Arnold and Co. for permitting the repro duction of Figs. 9 and 23 from similar figures which appeared in his book "The Mode of Action of Drugs on Cells"; portions of other figures from this book also have been reproduced in modified form. The author also desires to thank Dr. J. M. ROBSON for help in correction of the proofs. Edinburgh, July, 1937. A. J. CLARK. Contents.

Inhalt
1: Methods of General Pharmacology.- 2: The Cell as a Physico-chemical System.- 3: General Characteristics of the Cell-Drug System.- 4: Reactions between Drugs and Active Proteins.- 5: The Action of Drugs on Catalysts and Enzymes.- 6: Action of Heavy Metals on Enzymes in vitro and in vivo.- 7: Action of Various Enzyme Poisons in vitro and in vivo.- 8: Concentration-action Relations I.- 9: Concentration-action Relations II.- 10: Quantitative Pharmacology and the Theory of Humoral Transmission.- 11: Kinetics of Drug Action.- 12: The Rate of Action of Drugs on Cells.- 13: Time-concentrations Curves.- 14: Individual Variation of Response to Drugs.- 15: Relation between Various Types of Curves Expressing Response of Cells to Drugs.- 16: Special Problems Relating to Variation of Populations.- 17: Quantitative Aspects of Drug Antagonism and of Drug Synergism.- 18: Qualitative Aspects of Drug Antagonism.- 19: Alternative Theories of Drug Action.- 20: Quantitative Aspects of Chemotherapy.- 21: Conclusion.- Index of Authors.- Index of Subjects.