Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS).
The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Autorentext
Frank Miedema, PhD, is professor of Open Science, is Vice Rector for Research and chair of the Utrecht University Open Science Program. He studied biochemistry in Groningen specialising in Immunology, with a minor in the Philosophy of Science and in 1985 obtained a PhD from the University of Amsterdam. After a career in biomedical (HIV/AIDS) research in Amsterdam, from 1985 to 2004 as Director of the Research Division of Sanquin and professor in the immunology of HIV/AIDS at AMC, he moved to UMC Utrecht where from January 2009 to March 2019 he was dean and vice chairman of the Executive Board at the University Medical Center Utrecht.

Inhalt
Aids Pathogenesis: Table of Contents.- 1 HIV-1 transmission.- 2 Primary HIV infection.- 3 Biological variability of HIV-1.- 4 T-cell dynamics and renewal in HIV-1 infection.- 5 Long-term non-progressive HIV infection.- 6 Cytotoxic T lymphocytes in HIV-1 infection.- 7 Mechanisms and in-vivo significance of HIV-1 neutralisation.- 8 Suppression of primate immunodeficiency lentiretroviruses CD8+ T-cell-derived soluble factors.- 9 Opportunistic infections.- 10 AIDS-related non-Hodgkin's lymphomas.- Pathogenesis of Kaposi's sarcoma.- 11 AIDS dementia complex.- 12 Anti-retroviral therapy and resistance to anti-retroviral drugs.- 13 Prognostic markers and immunological reconstistution during HIV-1 infection.- 14 HIV-viral load.- 15 The SCID-hu mouse: an in-vivo model for HIV-1 infection in humans.- Non-human primate models for HIV-1 infection.