The 10th International Winter Conference on Neurodegeneration (lWCN) has taken place from February 14-16,2002, at the lovely "SchloB Ziethen", an old prussian manor (in Prussia, 'faute de mieux', called 'SchloB', i. e. cas tle or residence). This place is 20 km off Tegel Airport, Berlin's main airport, and has been beautifully restored by baroness Edith von Thiingen (nee von BUlow, i. e. of historical Prussian aristocracy); it lends itself rather perfectly for the IWCN type of small interdisciplinary workshops on neurodegenera tion which combine short lectures with plenty of discussion. In this context, we could quote Alexander von Humboldt's famous opening words for one of the first international scientific meetings held at Berlin, on September 18, 1828: "The main purpose . . . does not consist in a mutual reading of manuscripts all to be printed after at least one year in specialised publications, but in the personal communication amongst those who work in similar scientific fields; the oral and thus more stimulating exchange of ideas, might they represent facts, opinions or doubts; the foundation of friendly relations which convey illumination to our sciences, serene grace to our lives and tolerance and mildness to our habits . . . Berlin, Sept. 18, 1828 Alexander von Humboldt To the IWCN aficionado, it may come as a little surprise that this is the pub lication of the 10th Winter Conference as this might mean that they must have missed number 9.

Klappentext

From the contents:Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia.- Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model.- Progressive neurodegeneration in Drosophila: a model system.- Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer s disease.- What have we learnt form cDNA microarray gene expression studies about the role of iron in MPTP induced neurodegeneration and Parkinson s disease?.- Animal models of Parkinson s disease in rodents induced by toxins: an update.- General aspects of neurodegeneration.- The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour.- New concepts and tools in imaging for the study of neurodegenerative disease.- Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson s disease.- The role of acetylcholine and dopamine in dementia and psychosis in Parkinson`s disease.- Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-b superfamiliy, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning.- Gene therapy for Parkinson's disease.- Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson s disease.-

Inhalt
Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia.- Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model.- Progressive neurodegeneration in Drosophila: a model system.- Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease.- What have we learnt from cDNA microarray gene expression studies about the role of iron in MPTP induced neurodegeneration and Parkinson's disease?.- Animal models of Parkinson's disease in rodents induced by toxins: an update.- General aspects of neurodegeneration.- The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour.- New concepts and tools in imaging for the study of neurodegenerative disease.- Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson's disease.- The role of acetylcholine and dopamine in dementia and psychosis in Parkinson's disease.- Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-ß superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning.- Gene therapy for Parkinson's disease.- Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson's disease.