Willkommen, schön sind Sie da!
Logo Ex Libris

Advances in DNA Repair in Cancer Therapy

  • Fester Einband
  • 320 Seiten
(0) Erste Bewertung abgeben
Bewertungen
(0)
(0)
(0)
(0)
(0)
Alle Bewertungen ansehen
Leseprobe
This book details the biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in p... Weiterlesen
CHF 291.00
Print on Demand - Auslieferung erfolgt in der Regel innert 4 bis 6 Wochen.
Bestellung & Lieferung in eine Filiale möglich

Beschreibung

This book details the biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. It also reviews the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase.

A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

Reveals the latest developments in DNA repair in cancer therapy and the latest progress in research

Discusses novel DNA repair enzymes such as PARP and DNA-PK

Appeals to cancer researchers as well as oncologists



Klappentext

This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined.



Zusammenfassung
A comprehensive review of the recent developments in DNA repair research that have potential for translational applications.

Inhalt
Preface.- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs.- DNA-PK, a pharmacological target in cancer chemotherapy and
radiotherapy?.- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses.- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy.- Important Roles of ERCC1 in DNA Repair and Targeted Therapy.- The role of BRCA1 and BRCA2 in anticancer drug therapy.- DNA-PK in CLL Chemotherapy.- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair.- Cellular protection against the antitumor drug bleomycin.- ATR as a Therapeutic Target.- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy.- RAD51 is a key protein of DNA repair and homologous recombination in humans.- Index.

Produktinformationen

Titel: Advances in DNA Repair in Cancer Therapy
Editor:
EAN: 9781461447405
ISBN: 1461447402
Format: Fester Einband
Herausgeber: Springer New York
Genre: Medizin
Anzahl Seiten: 320
Gewicht: 647g
Größe: H241mm x B160mm x T22mm
Jahr: 2012
Auflage: 2013