This volume contains the accepted full papers and extended abstracts of the 5th Brazilian Symposium on Bioinformatics held in Bu zios, Rio de Janeiro, Brazil from August 31 to September 3, 2010. The ?rstthree meetings ofthis series,which took place2002,2003,and 2004, were called WOB (Workshop on Bioinformatics). In 2005, the conference got its current name BSB and has since published its proceedings as a special issue of the series Lecture Notes in Bioinformatics (volumes 3594/2005, 4643/2007, 5167/2008, and 5676/2009). Its topics of interest vary in many areas of bioinformatics, including - quence analysis, motifs, and pattern matching; biomedical text mining; biolo- cal databases, data management, integration;biologicaldata mining; structural, comparative, and functional genomics; protein structure, modeling, and si- lation; gene identi?cation and regulation; gene expression analysis; gene and protein interaction and networks; molecular docking; molecular evolution and phylogenetics;computationalsystemsbiology;computationalproteomics;stat- tical analysis of molecular sequences; algorithms for problems in computational biology; as well as applications in molecular biology, biochemistry, genetics, and associated subjects. WewouldliketothankallrefereesandProgramCommitteemembersfortheir carefulworkinpreparingthis proceedingsvolume.Also,wewanttoacknowlegde the local organizers and their sta? for making this meeting possible. September 2010 Carlos E. Ferreira Satoru Miyano Peter F. Stadler Organization BSB 2010 was promoted by the Brazilian Computing Society (SBC) and was organizedbytheInformaticsDepartmentofthePontif ?ciaUniversidadeCat olica do Rio de Janeiro (PUC-Rio).

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This book constitutes the proceedings of the 5th Brazilian Symposium on Bioinformatics, BSB 2010, held in Rio de Janeiro, Brazil, in August/September 2010. The 5 full papers and 5 extended abstracts presented were carefully reviewed and selected for inclusion in the book. The topics of interest vary in many areas of Bioinformatics, including sequence analysis, motifs, and pattern matching; biomedical text mining; biological databases, data management, integration; biological data mining; structural, comparative, and functional genomics; protein structure, modeling and simulation; gene identification, and regulation; gene expression analysis; gene and protein interaction and networks; molecular docking; molecular evolution and phylogenetics; computational systems biology; computational proteomics; statistical analysis of molecular sequences; algorithms for problems in computational biology; as well as applications in molecular biology, biochemistry, genetics, and associated subjects.

Inhalt
Full Papers.- Evolution of the Long Non-coding RNAs MALAT1 and MEN?/?.- Granger Causality in Systems Biology: Modeling Gene Networks in Time Series Microarray Data Using Vector Autoregressive Models.- Semi-supervised Approach for Finding Cancer Sub-classes on Gene Expression Data.- Bounds on the Transposition Distance for Lonely Permutations.- Insights on Haplotype Inference on Large Genotype Datasets.- Extended Abstracts.- An SVM Model Based on Physicochemical Properties to Predict Antimicrobial Activity from Protein Sequences with Cysteine Knot Motifs.- Enabling Annotation Provenance in Bioinformatics Workflow Applications.- BAT: A New Biclustering Analysis Toolbox.- Detection of Protein Domains in Eukaryotic Genome Sequences.- Discretization of Flexible-Receptor Docking Data.