This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.

Presents the core algorithms and mathematical models for sequence analysis Provides systematic and detailed methodologies and application Includes the most recent progress in the field Includes supplementary material: sn.pub/extras

Autorentext
Dr. Dongqing Wei is professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, China. He serves as Editor-in-Chief for journal of Interdisciplinary Sciences-Computational Life Sciences. He is chairman of International Association of Scientists in the Interdisciplinary Areas (IASIA). Prof. Wei's research is in the general area of structural bioinformatics. He has made many important contributions to sciences. With more than 150 journal papers and SCI 3000 citations, he is becoming a leading figure in the area of structural bioinformatics. Prof. Wei organized a few important international conferences recently, for example, International Conference on Computational and System Biology, 2009-2011, Shanghai, China; Theory and Application of Computational Chemistry, Sept. 23-27, 2008, Shanghai, China; 2nd IEEE Conferences on Bioinformatics and Biomedical Engineering, May 16-20, 2008, Shanghai, China.

Inhalt
Introduction to Structural Bioinformatics.- Modeling and Structure Determination.- The Structure Prediction of Biological Macromolecules.- The Biological Macromolecules in Computational Biology.- The Functional Analysis of Biological Macromolecules.- The Structure-Based Drug Design.