This special issue of Molecular and Cellular Biochemistry contains twenty-two selected research papers and reviews from a total of one hundred and ten presentations given at the 12th International Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to Cancer, held in Cancun, Mexico, May 10-14, 1997. The Symposium was hosted by the Sociedad Mexicana de Bioquimica and was sponsored by the University of North Texas Health Science Center, Fort Worth, TX, USA.
This volume provides a state-of-the-art source of information for basic scientists and clinicians who are interested in the molecular, biochemical, and cellular aspects of protein-(ADP-ribose) transfer reactions in human health and disease.

Klappentext

This special issue of Molecular and Cellular Biochemistry contains twenty-two selected research papers and reviews from a total of one hundred and ten presentations given at the 12th International Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to Cancer, held in Cancun, Mexico, May 10-14, 1997. The Symposium was hosted by the Sociedad Mexicana de Bioquimica and was sponsored by the University of North Texas Health Science Center, Fort Worth, TX, USA. This volume provides a state-of-the-art source of information for basic scientists and clinicians who are interested in the molecular, biochemical, and cellular aspects of protein-(ADP-ribose) transfer reactions in human health and disease.

Inhalt
Poly ADP-ribosylation: A DNA break signal mechanism.- Measurement of poly(ADP-ribose) glycohydrolase activity by high resolution polyacrylamide gel electrophoresis: Specific inhibition by histones and nuclear matrix proteins.- Regulatory mechanisms of poly(ADP-ribose) polymerase.- Poly(ADP-ribose) polymerase: A guardian of the genome that facilitates DNA repair by protecting against DNA recombination.- Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells.- Clostridial toxins: Molecular probes of Rho-dependent signaling and apoptosis.- Role of brefeldin A-dependent ADP-ribosylation in the control of intracellular membrane transport.- A dual approach in the study of poly (ADP-ribose) polymerase: In vitro random mutagenesis and generation of deficient mice.- The RT6 (Art2) family of ADP- ribosyltransferases in rat and mouse.- Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis.- Molecular heterogeneity and regulation of poly(ADP-ribose) glycohydrolase.- Niacin defiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment.- Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.- Identification of the archaeal NMN adenylyltransferase gene.- Functional analysis of poly(ADP-ribose) polymerase in Drosophila melanogaster.- Characterization of NAD:arginine ADP-ribosyltransferases.- The CD38-cyclic ADP-ribose signaling system in insulin secretion.- Newly discovered anti-inflammatory properties of the benzamides and nicotinamides.- Poly(ADP-ribose) turnover in quail myoblast cells: Relation between the polymer level and its catabolism by glycohydrolase.- Involvement of PARP and poly(ADP-ribosyl)ationin the early stages of apoptosis and DNA replication.- Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice.- Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors.- Index to Volume 193.