Abl Family Kinases in Development and Disease

Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.

This new title provides a comprehensive review of how Abl family kinases relay signals from cell surface receptors and coordinate cellular responses including cell migration, cell death, neuronal morphogenesis. Abl Family Kinases in Development and Disease includes an up-to-date view of how oncogenic mutant Abl kinases cause leukemia.

Inhalt
Mechanisms of Activation of Abl Family Kinases.- Role of Abl Family Kinases in Growth Factor-Mediated Signaling.- Regulation of Cell Adhesion Responses by Abl Family Kinases.- Abl and Cell Death.- Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases.- Regulation of Cell Motility by Abl Family Kinases.- Oncogenic Forms of ABL Family Kinases.- Abl Family Kinases in Mammalian Development.- Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity.