Reviews all important aspects of treatment-resistant psychiatric disorders Examines the most recent thinking on causes of treatment resistance Discusses treatment resistance in each of the major psychiatric disorders Provides detailed information on pharmacological and non-pharmacological therapeutic interventions

Autorentext
Yong-Ku Kim, MD, PhDDepartment of Psychiatry, Korea University Ansan Hospital, South Korea

Zusammenfassung
This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.

Inhalt

Part I. Rethinking the treatment resistance in psychiatry

Chapter 1. Definition and epidemiology of treatment resistance in psychiatry

Sanne Smith-Apeldoorn, Jolien Veraart, Robert Schoevers Department of Psychiatry, University Medical Center Groningen, University of Groningen, the Netherlands

Chapter 2. Paradigm shift in study of treatment resistant psychiatric disorder

Sang-Won Jeon 1 Meysam Amidfar,2 Yong-Ku Kim3

1 Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

2 Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

3 Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea

Chapter 3. Genetic factors underlying treatment resistance in psychiatry

Eduard Maron, Chenchia Lan, David Nutt

Faculty of Medicine, Department of Medicine, Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK

Chapter 4. Using neuroimaging and electroencephalography for

prediction of treatment resistance in psychiatric disorders

Je_Yeon Yun, 1Seung-Hwan Lee2

1Seoul National University Hospital, Seoul, Republic of Korea

2 Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine,

Republic of Korea.

Chapter 5. Developing therapies for treatment-resistant depressive disorders in animal models

Michel Bourin
Neurobiology of anxiety and mood disorders, University of Nantes, France

Chapter 6. Integrated approaches to treatment-resistant psychiatric disorders

Seon-Cheol Park,1 Yong-Ku Kim2

1 Department of Psychiatry, Inje University College of Medicine and Haeundae Paik Hospital, Busan, Republic of Korea

2 Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea

Part II. Treatment resistance in specific disorders

Chapter 7. Treatment resistant depression: understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Eunsoo Won, Byoung-Joo Ham, Yong-Ku Kim,

Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea

Chapter 8. Treatment Resistant Schizophrenia: assessment and management Sandeep Grover, Harsh Garekar, Anisha Agarwal
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India ****

Chapter 9. Treatment resistance in bipolar disorders

Marsal Sanches, Joao Quevedo, Jair C, Soares

Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

Chapter 10. Treatment resistance in post-traumatic stress disorder Alexander Cowell McFarlane,****

The Centre for Traumatic Stress Studies, The University of Adelaide, Adelaide, Australia

****

Chapter 11. Treatment resistance in obsessive compulsive disorder

Rachel Middleton, Michael G. Wheaton, Reilly Kayser, H. Blair Simpson

New York State Psychiatric Institute/Columbia Psychiatry, Columbia University Medical Center, New York, USA &a...