This book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these conditions occur. Based on these findings, a series of novel treatment strategies are currently under development, and hopefully in a few years, medical practitioners will become more confident and optimistic when facing patients with these annoying and sometimes severe disorders. The contributing authors are world-renowned research scientists, who have made significant discoveries. The book is of interest to neuroscientists, neurologists and pharmacologists involved in both basic and clinical work relevant to the research and treatment of pain and/or itch.

Autorentext
Chao Ma is a professor and director of Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences. He was awarded Union Scholar in 2011. His research mainly focuses on the molecular study of chronic pain and itch. Yuguang Huang is a professor and head of Department of Anesthesiology, Peking Union Medical College Hospital. He is the executive director of International Society for Anesthetic Pharmacology and president of China Anesthesiology Association. His research interests are the clinical anesthetic management for high risk cases, patient-controlled analgesia and regional blockade with nerve stimulator technique, as well as drug interactions for pain management.

Inhalt
Assessment of Itch vs. Pain in Animal Models and Human Subjects.- Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse.- Modulation of c-nociceptive Activities by Inputs from Myelinated Fibers.- New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation.- Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury.- Peripheral Nociceptors as Immune Sensors in the Development of Pain and Itch.- Mas-related G protein-coupled Receptors Offer Potential New Targets for Pain Therapy.- Pain Modulation and Transition from Acute to Chronic Pain.- Advances in the Study and Treatment of Neuropathic Pain.- Integrated, team-based Chronic Pain Management: Bridges from Theory and Research to High Quality Patient care.