This book reviews the role of trace elements in brain development, function, metabolism, and neurodegenerative disorders. It explores the molecular mechanisms of the effects of trace elements on metabolic pathways, mitochondrial nutrients, neurodegeneration, Central Nervous System (CNS) disorders, cell signaling, and neuronal functions. The book also discusses transport mechanisms of trace elements within CNS and their impact on neurotransmitter biology. Further, it examines the deleterious effects due to dyshomeostasis of trace elements in the central nervous system (CNS), resulting in damage to neurons and glial cells through the generation of reactive oxygen species and oxidative stress turn leading to neurodegeneration and neurological dysfunction. The book also explores the putative role of trace element deficiency in psychiatric disorders, including depression, and the imbalance of trace elements on neuronal genomic stability.

Autorentext

Dr. Wael Mohamed Yousef Mohamed is a Clinical Pharmacologist, Neuroscientist and Psychiatrist. Dr. Mohamed got his PhD from PSU, USA and is currently working as an Assistant Professor in IIUM Medical School, Malaysia. He published over 70 peer-reviewed papers related to Neuroscience/Psychiatry. He is an editor of the Frontiers in Neurology, and PLOS-ONE Journals Additionally, he has edited few books in neuroscience field with Springer and Cambridge. He has received many research grants from national and international organizations namely, IBRO, ISN, MJF, STDF, FRGS and INDO-ASEAN.

Professor Rajat Sandhir has received his M.Sc and Ph.D. degree in Biochemistry from the Postgraduate Institute of Medical Education and Research, Chandigarh, India. Presently he is working as a Professor at the Department of Biochemistry, Panjab University. His research interests are focused to understand the biochemical and molecular mechanisms involved in development of neurodegenerative conditions like metabolic encephalopathies, dementia's and motor disorders with a particular interest to investigate the role of oxidative stress, mitochondrial dysfunctions and alterations in permeability of Blood-Brain-Barrier. In addition, his interest is also to identify neuroprotective strategies that ameliorate neurodegenerative conditions. His group is also interested in understanding role of trace elements in brain particularly selenium during early development. He has over 200 research articles to his credit and has been on the editorial board of several international journals. He is also Fellow of Indian Academy of Neurosciences and Indian Association of Biomedical Scientists (IABMS). He has recently been awarded KT Shetty Memorial Oration 2021 by the Indian Academy of Neurosciences. He has been listed among the World 2% Scientists for the year 2020 released now by the Stanford researchers from Panjab University.