Proceedings of the NATO Advanced Research Workshop on Toxoplasmosis, held at Fontevraud, France, June 28 - July 2, 1992

Inhalt

Molecular Biology.- Allelic polymorphyism in Toxoplasma gondii: implications for interstrain mating.- Study of genetic polymorphism of Toxoplasma gondii through isoenzyme analysis.- Expression of apical organelle antigens by a Toxoplasma gondii genomic library.- Dense granule antigens of Toxoplasma gondii.- A strategy for cloning a DNA polymerase gene of Toxoplasma gondii.- Extrachromosomal DNA in the Apicomplexa.- Cell Biology.- Formation and modification of the parasitophorous vacuole occupied by Toxoplasma gondii.- The parasitophorous vacuole membrane surrounding T. gondii: a specialized interface between parasite and cell.- Toxoplasma gondii: Motility and Invasion.- Toxoplasma gondii: Patterns of bradyzoite-tachyzoite interconversion in vitro.- The growth and development of Toxoplasma gondii tissue cysts in vitro.- Recent advances in the glycobiology of Toxoplasma gondii.- Immunology.- Role of P30 in attachment and immunity to T gondii.- Secretory IgA, antibody to SAG1, H-2 class I-restricted CD8+ T-lymphocytes and the INT1 locus in protection against Toxoplasma gondii.- Factors responsible for development of toxoplasmic enchephalitis in immunocompromised hosts.- Synergistic and compensatory roles of CD4+, CD8 + T-lymphocytes and natural killer cells in resistance to Toxoplasma gondii.- Human T-cell clones as tools to identify protective antigens of Toxoplasma gondii.- Protection of mice and nude rats against Toxoplasmosis by an octomaeric construct of the P30 48-67 peptide.- Toxoplasmosis Vaccines Diagnosis & Chemotherapy.- Synergistic drug combinations in the treatment of toxoplasmosis.- Toxoplasma gondii: Chemotherapy.- Diagnosis of Toxoplasma gondii infections by molecular detection.- Use of Toxoplasma gondii recombinant antigens for diagnosis and seroepidemiology.- Progress towards the development of a vaccine against congenital toxoplasmosis: Identification of protective antigens and the selection of appropriate adjuvants.- Development of a live vaccine against ovine toxoplasmosis.- Abstracts.- Genetic regulation of Toxoplasma gondii infection: influence of LSH/ITY/BCG gene.- Establishing a laboratory for parasitic genome analysis: focus on the parasitic protozoa Toxoplasma, Trypanosoma and Leishmania.- Mucosal immune response in Tpxoplasmosis.- Antenatal screening for Toxoplasmosis in Turkiye.- Toxoplasmosis in Greece: Serological studies.- Critical evaluation of IgA antibodies as an indication of early Toxoplasma-infection.- Expression of Toxoplasma gondii genes in rBCG.