Toxicologic Pathology for Non-Pathologists

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Autorentext
Thomas J. Steinbach DVM, DACVP, DABT (Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA) and Daniel J. Patrick DVM, DACVP, DABT (Charles River Laboratories, Inc., Mattawan, MI, USA) have worked for numerous years to help organize the successful "Pathology for Non-Pathologists" short course, created with the support of the American College of Toxicology (ACT) and Society of Toxicologic Pathology (STP), upon which this book is based. Mary Ellen Cosenza PhD, DABT, RAC, ATS (MEC Regulatory & Toxicology Consulting, LLC, Moorpark, CA, USA) was an inaugural committee member of this short course and remains a highly respected member of the community at large.

Inhalt

1. Introduction to Toxicologic Pathology

George A. Parker

2. The Pathology Report, Peer Review, and Pathology Working Group

Ted A. Birkebak and Peter C. Mann

3. Routine and Special Techniques in Toxicologic Pathology

Pamela Blackshear, Erica Carroll, Sasmita Mishra, Matthew Renninger, and Arun Tatiparthi

4. Pathology of the Liver and Gallbladder

Robert R. Maronpot and David E. Malarkey

5. Pathology of the Gastrointestinal Tract and Exocrine Pancreas

Mark J. Hoenerhoff and Arun Kumar R. Pandiri

6. Pathology of the Urinary System

Kendall S. Frazier

7. Pathology of the Nervous System

Juliana S. Lee, Sarah D. Cramer, and Mark T. Butt

8. Pathology of the Cardiovascular System

Joshua H. Decker, Radhakrishna Sura, and Paul W. Snyder

9. Pathology of the Respiratory System

Jack R. Harkema and James G. Wagner

10. Pathology of the Lymphoid System

Tracey L. Papenfuss, Marlon C. Rebelatto, and Brad Bolon

11. Pathology of the Male and Female Reproductive System and Mammary Gland

Justin D. Vidal

12. Pathology of the Integumentary System

Kelly L. Diegel

13. Pathology of the Endocrine System

Brent E. Walling and Thomas J. Rosol

14. Pathology of Bone, Skeletal Muscle, and Tooth

Stacey Fossey, D. Greg Hall, Andrew Suttie, Martin Guillot, and Aurore Varela

15. Pathology of the Eye

Leandro B.C. Teixeira

16. Pathology of the Ear

Kenneth A. Schafer

17. Principles of Toxicologic Clinical Pathology

Adam Aulbach and Laura Cregar

18. Carcinogenicity

Paul Howroyd

**19. Patho...