This book constitutes the refereed proceedings of the 14th EAI International Conference on Towards new e-Infrastructure and e-Services for Developing Countries, AFRICOMM 2022, which was held in Zanzibar, Tanzania, in December 2022. The 30 papers presented in this volume were carefully reviewed and selected from 78 submissions. The papers are organized in the following topical sections: E-infrastructure; E-Services (Farming); E-Services (Health); E-Services (Social); E-Services (Education); and Advanced ICT.