Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.

Autorentext
Thomas J. Polascik MD FACS
Department of Surgery, Duke Cancer Institute, Durham, NC, USA

Klappentext

Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail.

Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.

Inhalt
Focal Therapy in Other Genitourinary Systems: Renal Cell Carcinoma.- Changing Landscape of Prostate Cancer Favoring Low Risk Prostate Cancer: Implications for Active Surveillance Versus Focal Therapy.- Active Surveillance and Focal Therapy: A European Perspective.- Pathologic Basis for Focal Therapy: Understanding Cancer Grade, Volume and Spatial Location.- Identifying the Index Lesion.- Molecular Identification of the Indolent Versus Lethal Tumor.- Biopsy Strategies to Detect Small Prostate Cancers.- 3-D Image-guided Mapping Biopsy for Defining Spatial Distribution of Prostate Cancer.- Stereotactic, Image-guided Robotic Biopsy.- Multimodality MRI-guided Targeting.- Quality Assurance in Prostate Biopsy Sampling, Processing, and Reporting: A New Pathologic Paradigm for Prostate Cancer Diagnosis.- Contrast-enhanced Ultrasonography.- Prostate Elastrography.- Multi-parametric Magnetic Resonance Imaging Approaches in Focal Prostate Cancer Therapy.- Nanomedicines for Diagnosis and Treatment of Prostate Cancer.- New Horizons in Molecular Imaging of Prostate Cancer.- Prostate Focal Therapy: Definitions and Common Terminology.- Selection Criteria for Focal Therapy of Prostate Cancer.- Standardization of Focal Therapy Protocols.- High Intensity Focused Ultrasound.- Photodynamic Therapy for Early Prostate Cancer.- MRI-guided Laser Ablation for Localized Prostate Cancer.- Cell Electroporation Mechanisms and Pre-clinical Foundation for Focal Therapy.- Histotripsy.- Cryoablation.- Optimizing Ablative Therapy: Manipulating the Microenvironment.- Setting Rules for Postablation and Follow-up.- Roadmap for Focal Therapy.