This book is a detailed guide to therapy response imaging in cancer patients that fully takes into account the revolutionary progress and paradigm shift in treatment approaches for advanced disease. The opening chapters describe the role of imaging as a "common language" for tumor response evaluation in oncology and address challenges and strategies in the era of precision cancer therapy and cancer immunotherapy. Practical pitfalls are discussed, with emphasis on the importance of approaching cancer as a systemic disease and the need for increased awareness of drug toxicity due to novel therapies. Therapy response imaging in a wide range of cancer types is then comprehensively described and illustrated, using a disease-specific approach. A concluding section focuses on emerging approaches and future directions, including radiomics/radiogenomics, co-clinical imaging, and molecular and functional imaging. Therapy Response Imaging in Oncology will be of high value for radiologists,nuclear medicine physicians, and oncologists. It will also be of interest to cancer care providers and oncology trial investigators.

Autorentext
Mizuki Nishino is a diagnostic radiologist specialized in oncologic imaging, with a particular focus on therapy response imaging in the setting of precision cancer therapy and cancer immunotherapy. Dr. Nishino is a fellowship-trained thoracic radiologist. Her research has focused on therapy response imaging in lung cancer treated with molecular targeting therapy, contributing to the identification of objective imaging markers to predict treatment benefit and clinical outcome. Dr. Nishino has also applied her expertise to therapy response imaging in cancer immunotherapy and has published a series of fundamental studies to refine strategies for immune-related response evaluation. In addition she has made contributions to imaging-based characterization of drug toxicities in cancer patients treated with precision therapy and immunotherapy. Dr. Nishino published the first report of clinical and imaging characteristics of immune checkpoint inhibitor-related pneumonitis, defined the spectrum of radiographic manifestations of the entity, and continues to work on the topic to develop strategies for early detection and accurate diagnosis.

Inhalt

Part I Imaging as a Common Language for Treatment Response Evaluations in Oncology

Conventional Tumor Response Criteria and Limitations

Response Evaluations for Precision Cancer Therapy and Immunotherapy

Part II Practical Pitfalls in Therapy Response Imaging in Cancer Patients

Drug Toxicity, Approach to Cancer as a Systemic Disease, and imaging modality-specific considerations

Part III Disease-specific Approach for Therapy Response Imaging

Therapy Response Imaging in Central Nervous System (CNS) Malignancy

Therapy Response Imaging in Breast Cancer

Therapy Response Imaging in Thoracic Malignancy

Therapy Response Imaging in Gastrointestinal Malignancy

Therapy Response Imaging in Hepatobiliary and pancreatic malignancies

Therapy Response Imaging in Genitourinary Malignancies 

Therapy Response Imaging in Gynecologic malignancies

Therapy Response Imaging in Lymphoma and Hematologic Malignancies

Therapy Response Imaging in Sarcoma and musculoskeletal malignancies

Part IV: Emerging Approaches and Future Directions

Radiomics and Imaging Genomics for Evaluation of Tumor Response

Evolution of Clinical Trial Imaging and Co-clinical Imaging

Molecular and Functional Imaging in Oncology Therapy Response