This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.

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Part I High Intensity Focused Ultrasound Ablation of Pathological Tissue.- Chapter 1. HIFU Tissue Ablation: Concept & Devices G. Ter Haar.- Chapter 2. Prostate Focused Ultrasound Therapy J.Y. Chapelon, O. Rouvière, S. Crouzet, A. Gelet.- Chapter 3. MRI-guided HIFU Methods for the Ablation of Liver and Renal Cancers B.D. de Senneville, C. Moonen, M. Ries.- Chapter 4. Magnetic Resonance-guided High Intensity Focused Ultrasound Ablation of Breast Cancer.- F.M. Knuttel, M.A.A.J. van den Bosch.- Chapter 5. HIFU for Palliative Treatment of Pancreatic Cancer.- T.D. Khokhlova, J.H. Hwang.- Chapter 6. MR-guided Transcranial Focused Ultrasound.- J.F. Aubry, M. Tanter.- Chapter 7. Focused Ultrasound & Lithotripsy.- T. Ikeda, S. Yoshizawa, N. Koizumi, M. Mitsuishi, Y. Matsumoto.- Chapter 8. Heat-based Tumor Ablation: Role of the Immune Response F. Wu.- Part II Drug and Gene Delivery using Bubble-assisted Ultrasound.- Chapter 9. Droplets, Bubbles and Ultrasound Interactions O. Shpak, M. Verweij, N. de Jong, M. Versluis.- Chapter 10. Sonoporation: Concept and Mechanisms A. Bouakaz, A. Zeghimi, A.A. Doinikov.- Chapter 11. Design of Microbubbles for Gene/Drug Delivery T. Bettinger, F. Tranquart.- Chapter 12. Co-administration of Microbubbles and Drugs in Ultrasound-assisted Drug Delivery: Comparison with Drug-carrying Particles R. Suzuki, A.L. Klibanov.- Chapter 13. Drug-loaded Perfluorocarbon Nanodroplets for Ultrasound-mediated Drug delivery N. Rapoport.- Chapter 14. Bubble-assisted Ultrasound: Application in Immunotherapy and Vaccination J.M. Escoffre, R. Deckers, C. Bos, C. Moonen.- Chapter 15. Sonoporation: Application for Cancer Therapy.- J. Qin, T.Y. Wang, J.K. Willmann.- Chapter 16. Microbubble-assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System A. Burgess, K. Hynynen.- Chapter 17. Microbubbles & Ultrasoun: Therapeutic Applications in Diabetic Nephropathy W.J. Cao, P.N. Matkar, H.H. Chen, A. Mofid, H. Leong-Poi.-Chapter 18. Drug and Gene Delivery using Sonoporation for Cardiovascular Disease J. Castle, S.B. Feinstein.- Chapter 19. Sonothrombolysis K.B. Bader, G. Bouchoux, C.K. Holland.- Part III- Other Ultrasound Therapy.- Chapter 20. Ultrasound-mediated Polymeric Micelle Drug Delivery H. Xia, Y. Zhao, R. Tong.- Chapter 21. Stimulation of Bone Repair with Ultrasound.- F. Padilla, R. Puts, L. Vico, A. Guignadon, K. Raum.- Chapter 22. Sonodynamic Therapy: Concept, Mechanism & Application to Cancer Treatment A.P. McHale, J.F. Callan, N. Nomikou, C. Fowley, B. Callen