The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade. Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike.

Autorentext
Yukihito HigashiHiroshima University, Research Institute for Radiation Biology and Medicine
Toyoaki MuroharaNagoya University, Department of Cardiology

Inhalt
Chapter 1: Introduction Section: Over View of Therapeutic Angiogenesis.-
Part I : Cell Therapy.-Chapter 2: Autologous Bone Marrow Mononuclear Cell Implantation in Extremities with Critical Limb Ischemia.-Chapter 3: Peripheral Blood Mononuclear Cells for Limb Ischemia.-Chapter 4: Endothelial Progenitor Cells for Ischemic Diseases.-Chapter 5: Therapeutic Angiogenesis With Adipose Tissue-derived Regenerative Cells.-Chapter 6: Cell Therapy for Ischemic Heart Disease.-Chapter 7: Angiogenic Therapy for Ischemic Cardiomyopathy with Cell Sheet Technology.-
Part II: Gene Therapy.-Chapter 8: The Role of VEGF in Extremities.-Chapter 9: HGF Gene Therapy for Therapeutic Angiogenesis in Peripheral Artery Disease.-Chapter 10: Fibroblast Growth Factor in Extremities.-
Part III: Other Therapy.-Chapter 11: Low-intensity Pulsed Ultrasound.-Chapter 12: Low-energy Extracorporeal Shock Wave Therapy.-Chapter 13: Granulocyte-Colony Stimulating Factor.-Chapter 14: Waon Therapy: Effect of Thermal Stimuli on Angiogenesis.-Chapter 15: Exercise.-Chapter 16: Nanoparticle-mediated Endothelial Cell-selective Drug Delivery System.