Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti­ cal ischemia has prompted novel therapeutic strategies to stimulate/fa­ cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col­ lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en­ hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap­ plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis­ sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte­ rial or intravenous delivery.

Inhalt

Angiogenesis, Fibroblast Growth Factors and their Receptors; Integrins and Angiongenesis; Mechanisms of Brain Angiogenesis in Health; TIE Receptors and Angiopoietins: Novel Modulators of Angiogenesis; Collateral and Capillary Formation; Hemodynamic Forces, Exercise, and Angiogenesis; Atherosclerotic Plaque Angiogenesis: Some Cautionary Notes for Therapeutic Angiogenesis; Factors Affecting the Outcome of Therapeutic Angiogenesis (VEGF); Myocardial Ischemia and Growth Factor Therapy; Angiogenic Gene Therapy for Coronary Artery Disease; Early Clinical Results with Angiogenic Growth Factors.