Much progress has been made in elucidating the mechanisms regulating the induction and progression of inflammatory diseases. More recently, however, it has become apparent that the manipulation of mechanisms governing the resolution of inflammation is an important way to develop novel strategies for the therapy of such diseases. This book provides an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area (e.g. pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments). The chapters are written by leading scientists in the field.

This topical volume is of interest to medical and scientific researchers in academia and industry working on inflammatory and cardiovascular diseases such as arthritis, asthma, bronchitis, atherosclerosis, and more.

Zusammenfassung

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Inhalt
The resolution of acute inflammation: A 'tipping point' in the development of chronic inflammatory diseases.- Granulocyte apoptosis.- Innate immune mechanisms in the resolution of inflammation.- Cell surface molecular changes associated with apoptosis.- Fate of macrophages once having ingested apoptotic cells: Lymphatic clearance or in situ apoptosis?.- Novel lipid mediators in resolution and their aspirin triggered epimers: Lipoxins, resolvins, and protectins.- Beyond inflammation: Lipoxins; resolution of inflammation and regulation of fibrosis.- Anti-inflammatory glucocorticoids and annexin 1.- The resolution of airway inflammation in asthma and chronic obstructive pulmonary disease.- Resolution of glomerular inflammation.- Resolution of mucosal inflammation.