One of the first major theoretical reviews of schizophrenia since the publication of the 5th edition of the APA's Diagnostic and Statistical Manual, the DSM-5, this volume is a landmark in the history of schizophrenia research. It assembles recent groundbreaking developments in research on schizophrenia and reaffirms its central place in the mental health research agenda. Significantly, this volume reflects the paradigmatic shift in schizophrenia research applied in parallel to new approaches in psychiatric diagnosis. New models and findings from across disciplines in recent years reflect a new and greater understanding of the workings of the brain, which, in turn, helps develop our knowledge of the neuro and psychological processes in schizophrenia. Consequently, this volume illustrates a historical convergence of psychology, psychopathology and the neurosciences in schizophrenia.

World-renowned leaders of the schizophrenia research community in fields such as neuroscience,

psychiatry, neuropsychology, and clinical psychology offer clear suggestions for further advances in psychological and medical interventions, assessment, prevention strategies, and research. And in keeping with other titles in the Nebraska Symposium on Motivation series, these papers are noteworthy for their depth of detail, scientific rigor, and clinical relevance.

Included among the topics:

• Cognitive organization as a dimension of individual differences and psychopathology.
• Neurodevelopmental genomic strategies in the study of the psychosis spectrum.
• Multimodal brain and behavior indices of psychosis risk.

• The NIMH Research Domain Criteria Project: new approaches to classifying psychotic spectrum disorders. The Neuropsychopathology of Schizophrenia is one of the most forward-thinking and engaging treatments of the field in recent years, and is an indispensable text for all researchers, academics, and clinicians who t reat or

  study mental illness, especially psychiatrists, psychologists, mental health practitioners, and neuroscientists specializing in schizophrenia.

  Autorentext

Dr. Ming Li received his Bachelor and Master degrees in psychology from Beijing University in 1991 and 1996 respectively. After that, he went to the University of Toronto and studied under the supervision of Professor Alison Fleming on the neuroanatomical substrates of maternal memory in rats. He received his PhD in 2002. He then joined Professor Shitij Kapur's lab as a postdoctoral fellow at the Centre for Addiction and Mental Health, Toronto, and completed his postdoctoral training in 2005. Dr. Li joined the psychology faculty at the University of Nebraska-Lincoln in 2005. His research interests are focused in the field of behavioral pharmacology. Specifically, he is interested in developing animal models of schizophrenia, and understanding the neurobiological and behavioral mechanisms of action of antipsychotic drugs. His work is supported by the major federal and state funding agencies, and several research foundations.

Dr. Spaulding received his Ph.D. from the University of Arizona in 1976 and completed a postdoctoral Fellowship in Mental Health Research and Teaching at the University of Rochester, 1976-1979. He joined the UN-L faculty in 1979. His research interests address various aspects of schizophrenia and other severe disorders, including clinical and experimental psychopathology, the effectiveness of treatment and rehabilitation, and service systems and social policy.

Inhalt

Forward.- 1. Volume editors' introduction.- 2. Neurodevelopment genomic strategies in the study of the psychosis spectrum.- 3. Alterations in prefrontal cortical circuitry and cognitive dysfunction in schizophrenia.- 4. Visual perception in schizophrenia: A unified model.- 5. Avolition, negative symptoms and a clinical science journey and transition to the future.- 6. An affective neuroscience model of impaired approach motivation in schizophrenia.- 7. Multimodal brain and behavior indices of psychosis risk.- 8. Changing the diagnostic concept of schizophrenia: The NIMH Research Domain Criteria Initiative.