The Laboratory Mouse

Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimer's, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.

One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model.

• Edited by Hans Hedrich, Hannover Medical School
• Comprehensive reference source written by international experts
• Well-illustrated with high quality detailed images
• Two-color, user-friendly format combined with color plate sections

Inhalt

History, Development and Genetics of the Mouse as a Laboratory Model
Origin of the Laboratory Mouse and Related
Historical Foundations
Strain, Stock and Mutants
Mouse Genomics
Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis
The Mouse as an Animal Model for Human Diseases
The Mouse in Preclinical Safety Studies
Anatomy and Developmental Biology
Gross Anatomy
Normative Histology of Organs
Imaging
Introduction to Early Mouse Development
Pathophysiology (including non-infectious diseases)
Skin and Adnexes of the Laboratory Mouse
Cardiovascular System
Respiratory Tract
Gastrointestinal System and Metabolism
Inbred Mouse Models for Autoimmune Disease
Hematology of the Mouse
The Social Behaviour of Mice and its Sensory Control
Neuroendocrine - Immune Network in Stress
Circadian Rhythms of the Mouse
Gerontology
Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stock of Laboratory Mice
Infectious Agents and Diseases
Viral Infections
Animal Husbandry and Production
Housing and Maintenance
Gnotobiology and Breeding Techniques
Assisted Reproduction and Cryopreservation
Health Monitoring
Nutrition of Laboratory Mice
Procedures
Legal Regulations for the Protection of Animals Used for Scientific Experiments
Necropsy Methods
Handling and Restraint
Routes of Administration
Collection of Body Fluids
Anaesthesia, Analgesia and Euthanasia