It has been over 40 years since the original report by Salmon and Daughaday demon­ strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri­ bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio­ logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

Inhalt

Historical Perspective: The Origins and Development of the Somatomedin Hypothesis, William H. Daughaday and William D. Salmon, Jr. Part I. Molecular Biology of the IGF System. Molecular Biology of IGF-I and IGF-II, Peter Rotwein. Regulation of IGF Gene Expression, P. Elly Holthuizen, Paul H. Steenbergh, and John S. Sussenbach. Molecular Biology of the Type 1 IGF Receptor, Haim Werner. Molecular Biology of the IGF-II/Mannose-6-Phosphate Receptor, Wieland Kiess. Molecular Biology of the IGF Binding Proteins, Guck T. Ooi and Yves R. Boisclair. Part II. Biological Actions of the IGFs. IGF-I Receptor Function: Transducing the IGF-I Signal into Intracellular Events, Vicky A. Blakesley, Andrew A. Butler, Anatolii P. Koval, Yumiko Okubo, and Derek LeRoith. Type 2 IGF Receptor-Mediated Events, S. Peter Nissley. Alternative IGF-Related Receptors, Kenneth Siddle and Maria A. Soos. IGF Binding Proteins as Modulators of IGF Action, Janet L. Martin and Robert C. Baxter. IGF-Independent Actions of the IGF Binding Proteins, Youngman Oh and Ron G. Rosenfeld. IGF Binding Proteins and Extracellular Matrix, David R. Clemmons. Biological Actions of Proteolytic Fragments of the IGF Binding Proteins, Michel Binoux, Claude Lalou, and Sarah Mohseni-Zadeh. The IGF Binding Protein Superfamily, Vivian Hwa, Youngman Oh, Christine P. Burren, Won Kyu Choi, Donna L. Graham, Angela Ingermann, Ho-Seong Kim, Abel Lopez-Bermejo, Giuseppe Minniti, Srinivasa R. Nagalla, Kisoo Pai, Anna Spagnoli, Peter Vorwerk, Don L.V. Wanek, Elizabeth M. Wilson, Yoshitaka Yamanaka, Doo Hyun Yang, and Ron G. Rosenfeld. IGFs and Cell Growth, Renato Baserga, Marco Prisco, and Atsushi Hong. Posttranslational Modification of the IGF Binding Proteins, Cheryl A. Conover. Part III. IGF Physiology. IGFs in the Female Reproductive System, Linda C. Giudice. The IGF Axis in the Male Reproductive System, Stuart A. Weinzimer and Pinchas Cohen. IGFs and the Nervous System, Philip S. Leventhal, James W. Russell, and Eva L. Feldman.IGF System Components and Their Role in Bone Metabolism, Subburaman Mohan and David J. Baylink. IGFs and Skeletal Muscle, Stephen M. Rosenthal. IGFs and the Digestive Tract, P. Kay Lund. Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models, A. Joseph D'Ercole. Part IV. Clinical Aspects of the IGFs. Metabolic Effects of IGFs, Jürgen Zapf, E. Rudolph Froesch, and Christoph Schmid. Clinical Uses of IGF-I and IGF Binding Protein Assays, Louis E. Underwood. IGF Binding Protein Proteolysis in Various Clinical States, Laura A. Maile, Anna L. Crown, and Jeff M.P. Holly. IGF Deficiency, Katie A.Woods and Martin O. Savage. Tumor Hypoglycemia Linked to IGF-II, Christian A. Koch, Kristina I. Rother, and Jesse Roth. IGFs in the Evaluation of Acromegaly, Marlys R. Drange and Shlomo Melmed. IGF in the Treatment of Diabetes, Robert A. Gabbay and Alan C. Moses. IGF-I Treatment of Growth Hormone Insensitivity, Arlan L. Rosenbloom. Index.