This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.

Inhalt

Part I: Biological Characterization of Bone Tissue.- Chapter 1. Bone: functions, structure and physiology.- Chapter 2. Bone Quality Assessment at the Atomic Scale.- Part II: Bone Remodelling algorithms.- Chapter 3. Meshless, Bone Remodelling and Bone Regeneration Modelling.- Chapter 4. Dynamic biochemical and cellular models of bone physiology: integrating remodeling processes, tumor growth and therapy.- Chapter 5. Mathematical Modelling of Spatio-Temporal cell dynamics observed during Bone Remodelling.- Chapter 6. A Mechanostatistical Approach to Multiscale Computational Bone Remodelling.- Part III: Numerical simulation of bone tissue and adjacent structures.- Chapter 7. Finite Element Analysis of Bone and Experimental Validation.- Chapter 8. Computational modelling of tissue engineered cartilage constructs.- Chapter 9. On the Computational Biomechanics of the Intervertebral Disc.- Index.