This series was established to create comprehensive treatises on specialized topics in developmental biology. Such volumes are especially vital in develop­ mental biology, since it is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting-ground for the various practitioners of this science, facilitating an integration of heterogeneous infor­ mation on. specific topics. Each volume is intended to provide the conceptual basis for a comprehen­ sive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of devel­ opmental biology should understand the experimental background of the field and be able to place that body of information in context to ascertain where additional research would be fruitful. At that point, the creative process takes over, and new experiments are designed. This series is intended to be a vital link in that ongoing process of learning and discovery. If it facilitates schol­ arship, it will serve an important function.

Inhalt

I. The Cytoskeleton in Morphogenesis.- 1 . Cytoskeletal Dynamics in Animal Morphogenesis.- 1. Introduction.- 2. Organization of the Cytoskeleton.- 3. The Cytoskeleton of Adult Cells.- 4. Models of Function.- 5. Conclusions.- References.- 2 . Microtubules and the Cellular Morphogenesis of Plants.- 1. Introduction.- 2. Patterns of Cell Growth and Division.- 3. Microtubules during Interphase.- 4. Microtubules in Dividing Cells.- 5. Cells into Tissues.- References.- 3 . The Egg Cortex in Early Development of Sea Urchins and Starfish.- 1. Introduction.- 2. Surface Topography in Sea Urchin Embryogenesis.- 3. Topography of Maturing Starfish Oocytes.- 4. Submicrovillar Cortex in Situ.- 5. The Isolated Cortex.- 6. Cortical Contractility.- 7. The Cortex and the Integration of Embryogenesis.- References.- II. Cell-Cell Interactions in Development.- 4 . The Cellular Basis of Epithelial Morphogenesis.- 1. Introduction.- 2. Maintenance and Development of Epithelial Continuity.- 3. Intercellular Communication.- 4. Epithelial Polarity.- 5. Reshaping the Epithelium.- 6. Summary.- References.- 5 . Endogenous Lectins and Cell Adhesion in Embryonic Cells.- 1. Introduction.- 2. Strategies for the Detection of Lectin Activity.- 3. Animal Lectins: General Overview.- 4. Cellular Adhesion.- 5. What Do We Know about the Involvement of Lectins in Cell Adhesion?.- 6. Concluding Remarks.- References.- 6 . Cell-Cell Interactions during Sea Urchin Morphogenesis.- 1. Introduction.- 2. Morphological Studies of Cell Reaggregation.- 3. The Internal Clock of Embryonic Development in Sea Urchins.- 4. The Extracellular Matrix in Development.- 5. The Biochemistry of Cell Adhesion.- 6. Junction Formation during Development.- 7. Conclusions.- References.- 7 . The Cellular Basis of Amphibian Gastrulation.- 1. Introduction to Amphibian Gastrulation.- 2. Blastula Structure and Organization.- 3. Prospective Germ Layers and Major Morphogenetic Movements.- 4. Mechanism and Function of Epiboly in Gastrulation.- 5. Mechanism and Function of Convergent Extension.- 6. Migration of Involuted Mesodermal Cells.- 7. Bottle Cell Function in Gastrulation.- 8. Cell and Tissue Behavior as Related to Gastrulation.- 9. Analysis of Abnormal Gastrulation.- 10. The Diversity of Amphibian Gastrulation.- 11. Prospectus.- References.- 8 . Cell-Cell Interactions in Mammalian Preimplantation Development.- 1. Introduction.- 2. Morphology of the Embryo Surface.- 3. Molecules at the Cell Surface.- 4. Synthesis and Expression of Surface Glycoproteins.- 5. Developmental Processes Mediated by Cell-Cell Interaction.- 6. Conclusions and Future Directions.- References.- 9 . Molecular Basis for Teratocarcinoma Cell-Cell Adhesion.- 1. Introduction.- 2. Recent Progress in Studies on Cell Adhesion Molecules.- 3. Cell Adhesion Molecules of Teratocarcinoma.- 4. Molecular Mechanisms of Cell-Cell Adhesion by E-Cadherin.- 5. The Role of E-Cadherin in Early Embryonic Development.- 6. Concluding Remarks.- References.- III. Cell Migration.- 10 . Migration of Sea Urchin Primary Mesenchyme Cells.- 1. Introduction.- 2. Origins of the Primary Mesenchyme.- 3. Migration of the Primary Mesenchyme.- 4. Patterning of the Primary Mesenchyme Cells.- 5. Conclusions and Summary.- References.- 11 . Primordial Germ Cell Migration.- 1. Introduction-PGCs and Their Migratory Properties.- 2. The Migratory Route.- 3. Germ-Line Markers in the Study of PGC Migration.- 4. The Migratory Phenotype.- 5. Guidance of PGC Migration.- 6. Conclusions.- References.- 12 . Mesoderm Migration in the Early Chick Embryo.- 1. Introduction.- 2. Gastrulation.- 3. Intermediate Mesoderm and Area Vasculosa.- 4. Somitogenesis.- 5. Sclerotome.- 6. Somitic Contribution to Limb Bud Mesenchyme.- 7. Concluding Remarks.- References.- 13 . Morphogenesis of the Neural Crest.- 1. Introduction.- 2. Appearance of Crest Population and Initiation of Migration.- 3. Pathways of Migration.- 4. Crest Migratory Ability.- 5. Directionality of Migration.- 6. Cell Localization.- 7. Conclusions.- References.- IV. Cellular Dynamics in Morphogenesis.- 14 . On the Formation of Somites.- 1. History.- 2. Somite Origin and Sequence of Formation.- 3. The Stages of Somite Formation.- 4. The Mechanism of Somite Formation.- 5. The Fate of the Somite.- 6. Projections.- References.- 15 . Mechanisms of Axonal Guidance: The Problem of Intersecting Fiber Systems.- 1. Introduction.- 2. Historical Perspectives and Guidance Theories.- 3. Modern Synthetic Guidance Theories.- 4. Intersecting Fiber Systems.- 5. Corticoseptal Barricade and Intersection.- 6. Callosal Fiber Topography and the Subependymal Pathway.- 7. Conclusions.- References.- 16 . Formation of the Vertebrate Neuromuscular Junction.- 1. Introduction.- 2. Development of the Morphological Characteristics of the Neuromuscular Junction.- 3. Development of the Functional Neuromuscular Junction.- 4. Summary.- References.