The origins of tinnitus and the development of effective treatments to treat tinnitus have puzzled scientists and clinicians for centuries. Now ground breaking research is beginning to unlock its secrets. The Behavioral Neuroscience of Tinnitus provides critical and comprehensive discussions of the most recent developments in behavioral neuroscience research of tinnitus. Each chapter represents the most important contemporary account of the subject, with an emphasis on preclinical and clinical trials for the development of new diagnostics and therapeutics. New and emerging innovative approaches are covered whenever possible. Six topics are discussed in detail in this volume, which provide new insights in the etiology and mechanisms of tinnitus, new biomarkers towards objective and reliable diagnosis of tinnitus, pharmacological approaches towards curing tinnitus, bioengineering advances towards developing effective medical devices, as well as the latest in psychotherapy methods. The reviews in the volume expose researchers and clinicians, both new and experienced, to exciting advancements and state-of-the-art developments from preeminent researchers in the field of tinnitus.

Inhalt

Preface - Tinnitus: History and controversies

Part 1. Tinnitus in Humans

Epidemiology of tinnitus

Genetics and tinnitus

Part II. Preclinical and Clinical Models of Tinnitus

Pharmacological modelling of tinnitus in animals

Animal models of sensory and brain stimulation effects on tinnitus Cochlear damage and the mechanisms of tinnitus - implications for treatments

Part III. Developing Biomarkers for Tinnitus

Functional neuroanatomy of tinnitus

Neuroinflammation and tinnitus

Using big data to guide therapy development

Part IV. Pharmacotherapy and Neuromodulation of Tinnitus

Pharmacoltherapy for tinnitus Sound therapy devices and mechanisms

Cochlear electrical stimulation

Brain stimulation

Biomodal stimulation

Part V. Cognitive and Affective Aspects of Tinnitus

Effect of tinnitus on attention and cognition

Neurobiology of stress induced tinnitus

Behavioral correlates of tinnitus

Psychological aprroaches to tinnitus management

Part VI. Clinical Assessment of Tinnitus

Momentary evaluation

Questionnaires

Psychoacoustic evaluation of tinnitus