This book constitutes the refereed proceedings of the 16th IFIP WG 5.5/SOCOLNET Advanced Doctoral Conference on Computing, Electrical and Industrial Systems on Technological Innovation for AI-Powered Cyber-Physical Systems, DoCEIS 2025, held in Lisbon, Portugal, during July 2-4, 2025.

The 29 full papers presented were carefully reviewed and selected from 60 submissions. They were focused on topical sections as follows: AI in Business Applications; AI in Industry 4.0; Smart Systems in Sustainable Development; AI-Powered Healthcare; AI in Systems, Decision & Control; Intelligent Sensing & Communication Systems; Smart Power Systems; Electronic Systems.