Targeting Ion Channels for Cancer Treatment: Current Progress and Future ChallengesAlina L. Capatina, Dimitris Lagos, and William J. Brackenbury

Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer

Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho

Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk

Jerry J. Fan and Xi Huang

Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics

Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile

Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research

Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier

Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions

Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu

Ion Transport and Radioresistance

Bastian Roth and Stephan M. Huber

Ion Transporting Proteins and Cancer: Progress and Perspectives

Mustafa B. A. Djamgoz

Klappentext

This third and final volume in the "Ion Transport in Tumor Biology" collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed.

As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.

Inhalt

Preface

(Luis Pardo, Christian Stock)

1. Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges(Brackenbury)2. Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer(JavierCamacho)3. Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk(Xi Huang)4. Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics(Saverio Gentile)5. Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research(Christophe Vandier)6. Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions(Shuiying Hu)7. Ion Transport and Radioresistance(Bastian Roth)8. Ion Transporting Proteins and Cancer: Progress and Perspectives(Mustafa Djamgoz)