A concise guide to the recognition, understanding and management of childhood cancer. The text has been written by a multidisciplinary author team. It is particularly well suited for healthcare providers who manage childhood cancer survivors in long-term follow-up programs, and for those providers who are increasingly likely to encounter childhood cancer survivors in their practices. The symptom-specific tables and disease-specific algorithms make this reference easy to use in clinical settings.

Zusammenfassung
It was not long ago that clinicians would say,study ed at the 1975 meeting revealed. Among them was the late complications of cancer treatments we give to one based on data collected by the Late Effects Study children? You must be joking! We can start worrying Group, an international consortium that consisted about that when we start curing them! Meanwhile, initially of ?ve, then ten, pediatric centers. This was cure must be our only aim. These practitioners were the ?rst large scale, cooperative unit of its kind, - only partially correct in what seemed to be a glaring ganized speci?cally for the purpose of studying the truth, for, in fact, increasing numbers of children late effects of cancer therapy (the study of delayed were beginning to survive their malignancy,and the complications had been included as part of the or- long-term consequences of therapy would soon be- inal design in the National Wilms Tumor Study come critical. launched in 1969) [1]. These historical notes demon- It is well to remember that the delayed conse- strate that the epidemiologic,statistical and reco- quences of a cancer treatment delivered to develop- keeping mechanisms necessary for studying lo- ing organisms were ?rst studied long ago. It has been term survivors effectively were in the process of be- 100 years since Perthes reported in 1903 that growth ing established decades before the meeting in 1975.

Inhalt
Overview.- Algorithms of Late Effects by Disease.- Facilitating Assessment of Late Effects by Organ System.- Central Nervous System Effects.- Neuroendocrine Complications of Cancer Therapy.- Ocular Complications Due to Cancer Treatment.- Head and Neck.- Adverse Effects of Cancer Treatment of Hearing.- The Thyroid Gland.- Cardiovascular Effects of Cancer Therapy.- Pulmonary Effects of Antineoplastic Therapy.- Late Gastrointestinal and Hepatic Effects.- The Ovary.- The Testes.- Genitourinary.- Musculoskeletal, Integument, Breast.- Hematopoietic Stem Cell Transplantation.- Second Malignancies Following Treatment for Childhood Cancer.- Psychological Aspects of Long-Term Survivorship.- Legal Issues.- Methodological Issues in the Study of Survivors of Childhood Cancer.- Transition Issues.