This book highlights the latest developments in acute and delayed neurovascular injury studies including delayed cerebral vasospasm, early brain injury, micro-circulation compromise, spreading cortical depolarization, neuroinflammation, and long-term cognitive dysfunctions after subarachnoid hemorrhage. About 32 chapters cover original presentations from the 14th international conference on neurovascular events after subarachnoid hemorrhage, held in Los Angeles in October 2017. Neurosurgeons, neurologists, and neuro-ICU practitioners discuss clinical observations, new pilot treatments, clinical trials, academic and industrial interactions, including surgical and endovascular approaches, brain injury monitoring, new developments in brain imaging, ICU management, early brain injury scales and management, counter cortical depolarization management and anti-inflammation management. In addition, animal models used to study acute and delayed neurovascular events, the basic mechanisms of vascular, neuronal, and CSF physiology, new experimental treatment strategies, new frontiers in the treatment of neurovascular injuries, and new research directions are discussed.

Autorentext

Robert D. Martin, M.D. is Professor of the Floyd S. Brauer Chair in Anesthesiology at Loma Linda University, Loma Linda, California and has held this position since 2004.  He is a member of the Board of Trustees of Loma Linda University.  He is Board Certified in Pain Medicine and Anesthesiology.  His primary clinical interests have been in the areas of Cardiac Anesthesiology and Pain.  Dr. Martin was a pioneer in developing anesthesiology protocols for infant heart transplantation.

Warren Boling, M.D., FRCSC, FRACS is Professor, Program Director, and Chairman of the Department of Neurosurgery at Loma Linda University, Loma Linda, CA. He is the past president of the Society of Brain Mapping and Therapeutics and a member of the SBMT Board of Directors. He is a member of the Faculty Medical Group of Loma Linda University Board of Directors. Dr Boling is an academic neurosurgeon and investigator, his primary interests are in the research and neurosurgical aspects of brain imaging, epilepsy, neuro-oncology, and international medicine. He is an expert on the fine topographic detail of human neuro-anatomy, which has led to the identification of anatomical and functional relationships in the human brain.

Gang Chen, M.D., Ph.D. is professor and vice Director of the Department of Neurosurgery at The First Affiliated Hospital of Soochow University, Suzhou, China. He also severs as Director of the Translational Stroke Research Team, and as Chair of the Division of Science & Technology. Dr. Chen's research focuses on subarachnoid hemorrhage (SAH), which is a violent disease affecting the human health. In SAH, Dr. Chen has put forward Right time, Right therapy therapeutic principle. He continues to identify novel regulatory mechanisms in candidate proteins such as CyPA/CD147, neurexin-1/neuroligin-1, etc., and to evaluate the current development, challenges and potential clinical translation of these researches. Dr. Chen's research efforts have been supported by grants from the National Natural Science Foundation of China.

John H. Zhang, M.D., Ph.D. (Editor) Loma Linda University Medical School, Loma Linda, CA, is currently a Professor of Anesthesiology, Neurosurgery, Neurology, Basic Sciences (Physiology & Pharmacology), Pathology & Human Anatomy, and Nursing at Loma Linda University Medical Center. He also serves as Director of the Center for Brain Hemorrhage Research, as Vice-Chair of the Department of Basic Sciences (Chief of Division of Physiology), as Director of the Physiology Graduate Training Program, and as Director of the Basic Science Research Division in Anesthesiology. Dr. Zhang's research efforts have been supported by grants from the American Heart Association, National Institute of Health, and Department of Defense as well as other regional foundations and industry. Dr. Zhang has published more than 600 peer-reviewed articles and has been invited to speak in meetings, seminars, and grand rounds more than 300 times.

Inhalt
Chapter 1: Vasospasm: a personal odyssey Bryce Weir 
Chapter 2: History of Vasospasm Research in Japan: Commemoration of Professor Tomio OhtaKenji Kanamaru, M.D., Ph.D.
Chapter 3: Heparin Treatment in Aneurysmal Subarachnoid Hemorrhage: A Review of Human StudiesNicolas K. Khattar, MD, Esther Bak, BS, Andrew C. White, DO, Robert F. James, MD
Chapter 4: Subarachnoid Hemorrhage Related EpilepsyWarren Boling, Lydia Kore
Section 1: Basic Science Section
Chapter 5: Cell Culture Model to Study Cerebral Aneurysm BiologyAlejandra N Martinez, Ph.D, Crissey L. Pascale, M.S., Peter S. Amenta, M.D., Rachel Israilevich, B.S., Aaron S. Dumont, M.D.
Chapter 6: Rat model of intracranial aneurysm: Variations, usefulness and limitations of the Hashimoto ModelTomohiro Aoki, Haruka Miyata, Yu Abekura, Hirokazu Koseki, Kampei Shimizu 
Chapter 7: Possible involvement of caspase-independent pathway in neuronal death after subarachnoid hemorrhage in miceFumi Nakano, Lei Liu, Fumihiro Kawakita, Yoshinari Nakatsuka, Hirofumi Nishikawa, Takeshi Okada, Masato Shiba, Hidenori Suzuki
Chapter 8: Nox2- and Nox4 participate in ROS-induced neuronal apoptosis and brain injury during ischemia-reperfusion in RatsJinjin Wang, Yin Liu, Haitao Shen, Haiying Li, Zhong Wang, Gang Chen
Chapter 9: Link between receptors that engage in developing vasospasm after subarachnoid hemorrhage in miceFumi Nakano, Fumihiro Kawakita, Lei Liu, Yoshinari Nakatsuka, Hirofumi Nishikawa, Takeshi Okada, Masato Shiba, Hidenori Suzuki
Chapter 10: Aquaporin4 knockout aggravates early brain injury following subarachnoid hemorrhage through impairment of the glymphatic system in rat brainE Liu, Linlin Sun, Yixuan Zhang, Aibo Wang, Junhao Yan
Chapter 11: The role of galectin-3 in subarachnoid hemorrhage: A preliminary studyHirofumi Nishikawa, Fumi Nakano, Lei Liu, Yoshinari Nakatsuka, Takeshi Okada, Masato Shiba, Hidenori Suzuki
Chapter 12: 17-allylamino-demethoxygeldanamycin ameliorate microthrombosis via HSP90/RIP3/NLRP3 pathway after Subarachnoid Hemorrhage in ratsYuchun Zuo, Tibiao He, Peiqiang Liao, Kai Zhuang, Xiaoxin Yan, Fei Liu
Chapter 13: TAK-242, Toll-like receptor 4 antagonist, attenuates brain edema in subarachnoid hemorrhage miceTakeshi Okada, Liu Lei, Hirofumi Nishikawa, Fumi Nakano, Yoshinari Nakatsuka, Hidenori Suzuki
Chapter 14: Subarachnoid Hemorrhage Pattern Predicts Acute Cerebral Blood Flow Response in the RatJesse J. Liu, Jeffrey S. Raskin, Robin McFarlane, Ravi Samatham, Justin S. Cetas
Chapter 15: Toll-like receptor 4 and tenascin-C signaling in cerebral vasospasm and brain injuries after subarachnoid hemorrhageHidenori Suzuki, MD, PhD, Masashi Fujimoto, MD, PhD, Fumihiro Kawakita, MD, PhD, Lei Liu, MD, PhD, Fumi Nakano, MD, Hirofumi Nishikawa, MD, Takeshi Okada, MD, Kyoko Imanaka-Yoshida, MD, PhD, Toshimichi Yoshida, MD, PhD, Masato Shiba, MD
Chapter 16: Spreading depolarization during the acute stage of experimental subarachnoid hemorrhage in miceZelong Zheng, Michael SchoellRenan Sanchez-Porras, Christian Diehl, Andreas Unterberg, Oliver W. Sakowitz
Chapter 17: The PERK Pathway Plays a Neuroprotective Role during the Early Phase of Secondary Brain Injury Induced by Experimental Intracerebral HemorrhageJuyi Zhang, Peng Zhang, Chengjie Meng, Baoqi Dang, Haiying Li, Haitao Shen, Zhong Wang, Xiang Li, Gang Chen
Chapter 18: The Time-course of Cognitive Deficits in Experimental Subarachnoid HemorrhageZHENG Zhiyuan Vera, LAM Ping Kuen, POON Wai ...